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Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021

Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial

Brain and Behaviour https://doi.org/10.1002/brb3.2342
Masoumeh Rajabi-Naeeni,Mahrokh Dolatian,Mostafa Qorbani,Amir Abbas Vaezi,

Summary article by GrassrootsHealth

2 + 2 = 4
Expect to find that vitamin D is al least synergistic with Omega-3 for many health problems

Omega-3 and Vitamin D each treat many mental health problems - April 2018

Anticipate finding other synergistic combinations, such as:
Vitamin D + (Resveratrol or Curcumin or Querctin or Zinc)
Vitamin D + Magnesium
Vitamin D + Iron
Vitamin D + Vitamin K2

Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D.

The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.

A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).

Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.

Clinical trial registry
Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
 Download the PDF from VitaminDWiki

Intervention of Vitamin D for Depression

Meta-analyses of Vitamin D and Depression

Intervention of Omega-3 for Depression

VitaminDwiki - Sleep category starts with

99 items in sleep category

A few items in SLEEP category

Sleep and Omega-3:

11+ items with Anxiety in the title

This list is automatically updated

Items found: 16
Title Modified
New anxiety after age 50 predicts 2.1 X increased risk of Parkinson’s – July 2024 06 Jul, 2024
International Adolescent Anxiety and suicide rates - GBD April 2024 07 Apr, 2024
Half as much anxiety and sleep problems if get lots of vitamin D from food (excluded getting D from supplements) – Feb 2024 23 Feb, 2024
Anxiety, Vitamin D, Omega-3 - many studies 23 Feb, 2024
Low Vitamin D is associated with risk of Depression 5X, Stress 4.8 X, and Anxiety 3.9 X (Saudi Arabia college students) – July 2023 29 Jul, 2023
Parkinson’s – Vitamin D, bone density, insomnia, falls, poor sleep, anxiety – March 2019 10 May, 2023
Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022 22 Dec, 2022
Depression and Anxiety treatment with Vitamin D - probable molecular pathways - June 2022 21 Dec, 2022
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022 07 Oct, 2022
Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022 29 May, 2022
General Anxiety Disorder treated by weekly Vitamin D (50,000 IU -Omega-3, Mg also help) – Sept 2019 09 Dec, 2019
Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018 02 Sep, 2019
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018 10 Nov, 2018
Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018 19 Sep, 2018
Why is teen anxiety increasing so much (no mention of Magnesium, Vitamin D nor Omega-3) – Oct 2017 11 Oct, 2017
Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014 11 Feb, 2015

VitaminDwiki - Vitamin D and Omega-3 category contains

398 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (50 studies), Pregnancy (40 studies), Infant (33 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

Attached files

ID Name Comment Uploaded Size Downloads
16293 O3 D adi d additive.jpg admin 27 Sep, 2021 116.21 Kb 448
16292 Omeg-3 and Vitamin D additive.pdf admin 27 Sep, 2021 286.21 Kb 284