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Depression is treated by 2,000 IU of Vitamin D – 2 meta-analyses July 2022


The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials

Crit Rev Food Sci Nutr. 2022 Jul 11;1-18. doi: 10.1080/10408398.2022.2096560
Tuomas Mikola,Wolfgang Mar xORCID Icon,Melissa M. Lane,Meghan Hockey,Amy Loughma nORCID Icon,Sanna Rajapolvi, show all

Benefit varied widely with the type of depression

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Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta-analyses investigating the effect of vitamin D on depression have been inconsistent. This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials (RCT). General and clinical populations, and studies of ill individuals with systemic diseases were included. Light therapy, co-supplementation (except calcium) and bipolar disorder were exclusionary. Databases Medline, PsycINFO, CINAHL and The Cochrane Library were searched to identify relevant articles in English published before April 2022. Cochrane risk-of-bias tool (RoB 2) and GRADE were used to appraise studies.
Forty-one RCTs (n = 53,235) were included. Analyses based on random-effects models were performed with the Comprehensive Meta-analysis Software. Results for main outcome (n = 53,235) revealed a positive effect of vitamin D on depressive symptoms (Hedges’ g = -0.317, 95% CI [-0.405, -0.230], p < 0.001, I2 = 88.16%; GRADE: very low certainty). RoB assessment was concerning in most studies. Notwithstanding high heterogeneity, vitamin D supplementation = 2,000 IU/day appears to reduce depressive symptoms. Future research should investigate possible benefits of augmenting standard treatments with vitamin D in clinical depression.
PROSPERO registration number: CRD42020149760.
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VitaminDWiki - Depression summary


Vitamin D Intervention AND Depression 19 studies

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16 Meta-analyses of Depression

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Another meta-analysis in July 2022 also concluded that 2,000 IU decreased depression

  • The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials
    • https://doi.org/10.1080/10408398.2022.2096560 FREE PDF

Depression is helped best by more than Vitamin D monotherapy:


Depression and Omega-3 29 studies

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Depression and Magnesium 14 studies

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Created by admin. Last Modification: Sunday October 30, 2022 17:43:57 GMT-0000 by admin. (Version 16)

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18079 Dep2.jpg admin 11 Jul, 2022 20:30 101.46 Kb 112
18078 dep1.jpg admin 11 Jul, 2022 20:29 194.20 Kb 134
18077 Depression meta_CompressPdf.pdf PDF 2022 admin 11 Jul, 2022 20:29 460.08 Kb 67