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Depression is associated with low Magnesium – meta-analysis April 2015

Hypomagnesaemia linked to depression: a systematic review and meta-analysis.

Intern Med J. 2015 Apr;45(4):436-40. doi: 10.1111/imj.12682.
Cheungpasitporn W1, Thongprayoon C, Mao MA, Srivali N, Ungprasert P, Varothai N, Sanguankeo A, Kittanamongkolchai W, Erickson SB.
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

BACKGROUND: The reported risk of depression in patients with hypomagnesaemia is controversial.

AIM: The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia.

A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inception through October 2014. Studies that reported odds ratios, relative risks or hazard ratios comparing the risk of depression in patients with hypomagnesaemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Six observational studies (three cohort studies, two cross-sectional studies and a case-control study) with a total of 19,137 patients were identified and included in the data analysis. The pooled RR of depression in patients with hypomagnesaemia was 1.34 (95% CI, 1.01-1.79, I(2) = 33%). The association between depression and hypomagnesaemia was marginally insignificant after the sensitivity analysis including only cohort and case-control studies, with a pooled RR of 1.38 (95% CI, 0.92-2.07, I(2) = 24%).

CONCLUSION: Our study demonstrates a potential association between hypomagnesaemia and depression. Further studies assessing the benefits of treatment of hypomagnesaemia in patients with depression are needed.

PDF is available free at Sci-Hub  10.1111/imj.12682

See also VitaminDWiki

Pages listed in BOTH the categories Magnesium AND Depression

Pages listed in BOTH the categories Omega-3 AND Depression

See also web

Magnesium and Mental Health  see  is.gd/VDMag

Cited by 27 other studies as of Nov 2018

Dietary recommendations for the prevention of depression - 2017
Role of magnesium supplementation in the treatment of depression: A randomized clinical trial - 2017 free PDF
Nutrition and lifestyle intervention on mood and neurological disorders - 2017
Magnesium intake and depression: the SUN cohort - 2016