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Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018

Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial

Journal of Psychiatric Research, Volume 102, July 2018, Pages 72–80, https://doi.org/10.1016/j.jpsychires.2018.03.015
Norio Watanabea, , , Yutaka Matsuokab, , Mie Kumachic, , Kei Hamazakid, , Masaru Horikoshie, , Toshi A. Furukawaa,


Vitamin D and Omega-3 category starts with

387 Omega-3 items in category Omega-3 helps with: Autism (9 studies), Depression (29 studies), Cardiovascular (33 studies), Cognition (49 studies), Pregnancy (40 studies), Infant (31 studies), Obesity (13 studies), Mortality (6 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

Items in both categories Omega-3 and Depression are listed here:

Items in both categories Omega-3 and Sleep are listed here:

Depression reduced by Vitamin D as well

Anxiety studies include

8 VitaminDWiki pages with ANXIETY in title
This list is automatically updated

Items found: 12

 Download the PDF from Sci-Hub via VitaminDWiki

 HADS questionare from the web A lower HADS number is better

•The effectiveness of omega-3 PUFAs for prevention of depression was examined.
•Eighty nurses were randomly allocated to omega-3 or placebo for 13 weeks.
•Information about depression, anxiety and presenteeism was collected up to 52 weeks.
•No clinically important difference was comfirmed between two intervention arms.

The efficacy of omega-3 fatty acids for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of omega-3 fatty acids for hospital nurses. In a multi-center randomized trial, 80 junior nurses were randomly allocated to either omega-3 fatty acids (1200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid) or identical placebo pills for 13 weeks. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater at week 26 from the study enrollment.
Secondary outcomes included the

  • total score of the HADS at 13 and 52 weeks;
  • incidence of a major depressive episode;
  • severity of depression, anxiety, insomnia, burnout, and
  • presenteeism;
  • utility scores; and
  • adverse events at 13, 26 and 52 weeks.

The mean HADS score at baseline was 7.2.
At 26 weeks, adjusted mean scores on the HADS were

  • 6.32 (95% CIs of standard errors: 5.13, 7.52) in the intervention and
  • 6.81 (5.57, 8.05) in the placebo groups, respectively.

The coefficient of the group by time interaction was not statistically significant at 0.58 (−1.35, 2.50; P = 0.557).
Although the intervention group showed

  • significant superiority on the HADS score at 52 weeks,
  • depression severity at 52 weeks,
  • insomnia severity at 13 weeks, and
  • absolute presenteeism at 26 weeks,
    • no significant superiority or inferiority was observed on the other outcomes.

The additive value of omega-3 fatty acids was not confirmed regarding mental state and self-evaluated work efficiency.

Created by admin. Last Modification: Monday December 9, 2019 12:35:02 GMT-0000 by admin. (Version 12)
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018        
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Attached files

ID Name Comment Uploaded Size Downloads
9660 HADS scoring.pdf admin 07 Apr, 2018 14:44 35.72 Kb 795
9659 Omega-3 HADS.jpg admin 07 Apr, 2018 14:44 24.60 Kb 743
9658 Happy Nurses.pdf PDF 2018 admin 07 Apr, 2018 14:43 887.81 Kb 851