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Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018

Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial

Journal of Psychiatric Research, Volume 102, July 2018, Pages 72–80, https://doi.org/10.1016/j.jpsychires.2018.03.015
Norio Watanabea, , , Yutaka Matsuokab, , Mie Kumachic, , Kei Hamazakid, , Masaru Horikoshie, , Toshi A. Furukawaa,


Vitamin D and Omega-3 category starts with

328 Omega-3 items in category

Omega-3 and Vitamin D separately & together help with Autism, Depression, Cardiovascular, Cognition, Pregnancy, Infant, Obesity, Mortality, Breast Cancer, Smoking, Sleep, Stroke, Surgery, Longevity, Trauma, Inflammation, MS, etc
   See also - Overview: Omega-3 many benefits include helping vitamin D

Items in both categories Omega-3 and Depression are listed here:

Items in both categories Omega-3 and Sleep are listed here:

Depression reduced by Vitamin D as well

Anxiety studies include

 Download the PDF from Sci-Hub via VitaminDWiki

 HADS questionare from the web A lower HADS number is better

•The effectiveness of omega-3 PUFAs for prevention of depression was examined.
•Eighty nurses were randomly allocated to omega-3 or placebo for 13 weeks.
•Information about depression, anxiety and presenteeism was collected up to 52 weeks.
•No clinically important difference was comfirmed between two intervention arms.

The efficacy of omega-3 fatty acids for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of omega-3 fatty acids for hospital nurses. In a multi-center randomized trial, 80 junior nurses were randomly allocated to either omega-3 fatty acids (1200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid) or identical placebo pills for 13 weeks. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater at week 26 from the study enrollment.
Secondary outcomes included the

  • total score of the HADS at 13 and 52 weeks;
  • incidence of a major depressive episode;
  • severity of depression, anxiety, insomnia, burnout, and
  • presenteeism;
  • utility scores; and
  • adverse events at 13, 26 and 52 weeks.

The mean HADS score at baseline was 7.2.
At 26 weeks, adjusted mean scores on the HADS were

  • 6.32 (95% CIs of standard errors: 5.13, 7.52) in the intervention and
  • 6.81 (5.57, 8.05) in the placebo groups, respectively.

The coefficient of the group by time interaction was not statistically significant at 0.58 (−1.35, 2.50; P = 0.557).
Although the intervention group showed

  • significant superiority on the HADS score at 52 weeks,
  • depression severity at 52 weeks,
  • insomnia severity at 13 weeks, and
  • absolute presenteeism at 26 weeks,
    • no significant superiority or inferiority was observed on the other outcomes.

The additive value of omega-3 fatty acids was not confirmed regarding mental state and self-evaluated work efficiency.

Created by admin. Last Modification: Monday December 9, 2019 12:35:02 GMT-0000 by admin. (Version 12)

Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018        

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ID Name Comment Uploaded Size Downloads
9660 HADS scoring.pdf admin 07 Apr, 2018 14:44 35.72 Kb 190
9659 Omega-3 HADS.jpg admin 07 Apr, 2018 14:44 24.60 Kb 254
9658 Happy Nurses.pdf PDF 2018 admin 07 Apr, 2018 14:43 887.81 Kb 190
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