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Less depression in seniors taking enough Omega-3 – meta-analysis July 2018

Omega-3 Polyunsaturated Fatty Acids and Reduction of Depressive Symptoms in Older Adults: A Systematic Review and Meta-Analysis

Journal of Affective Disorders, online 27 July 2018,.https://doi.org/10.1016/j.jad.2018.07.057
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VitaminDWiki

Pages listed in BOTH the categories Intervention AND Depression

Pages listed in BOTH the categories Depression and Meta-analysis

Pages listed in BOTH the categories Depression and Omega-3


Highlights

  • Available evidence suggested the efficacy of n-3 PUFA treatment with dosage greater than 1.5g/d in reducing depressive symptoms among adults aged 60 or older
  • Our study searched ten databases and gray literature. Nine with low risk and bias studies were included, which made the results more comprehensive, accurate and credible compared with previous studies.
  • This review synthesized the effects of n-3 PUFAs on older adults with depressive symptoms and explored subgroup differences (comorbidity, baseline depression, dosage, ratio of EPA and DHA, intervention duration).
  • The current review used RVE in meta-regression to synthesize treatment effect size estimates, which could have produced more accurate results compared to traditional methods used in previous systematic reviews.
  • Omega-3 Polyunsaturated Fatty Acids and Reduction of Depressive Symptoms in Older Adults: A Systematic Review and Meta-Analysis


Objective
This study aimed to systematically review the efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplements in reducing depressive symptoms among older adults.

Methods
Relevant electronic databases were searched from their inception to 26 June 4, 2018, including MEDLINE, EMBASE, Web of Science, Cochrane Library, PsycINFO, Global Health databases, CINAHL, ClinicalTrials.gov and Chinese Biomedical Medicine Database. Two reviewers independently screened for eligible studies, extracted data, and assessed the studies using the Cochrane Collaboration's tool for assessing risk of bias. The effect size data were analyzed using robust variance estimation in meta-regression.

Results
Nine studies were included. The results showed n-3 PUFA supplements reduced depressive symptoms for older adults (d = -0.202, 95% CI = -0.463, 0.060), but the difference was not significant. Subgroup analysis found a statistically non-significant difference between n-3 PUFAs and control conditions in treating depressive symptoms among adults aged 60 or older. Meta-regression found interventions with dosage greater than 1.5g/d had an average effect size of -0.428, with a 95% confidence interval of -0.822 to -0.035, which is statistically significant. And the other meta-regression did not find significant moderating effects of depression with comorbid disease, baseline depression, intervention duration, and EPA–DHA ratio, potentially due to limited statistical power.

Created by admin. Last Modification: Thursday August 30, 2018 13:05:46 GMT-0000 by admin. (Version 2)
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