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Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

European Neuropsychopharmacology, online 5 October 2017
Cora Schefft a, Laura L.Kilarski b. Tom Bschor c, Stephan Köhler
https://doi.org/10.1016/j.euroneuro.2017.07.004

See also VitaminDWiki

Vitamin D and Omega-3 have decreased a lot recent decades

Zinc and Vitamin D category has 23 items

20 Most-visited pages in Depression category in VitaminDWiki

Id Page Hits Last modification Creator Categories
3315 Hypothesis: Some Mental Illness could be treated or prevented with vitamin D 20950
24 Jul, 2016 12:48
admin Depression
Treatment by Vitamin D
Top news
7681 Depression 20340
09 Jun, 2018 01:28
admin Depression
Category
5764 Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013 14499
14 Jun, 2016 02:26
admin Depression
Intervention
5777 Suicide associated with low vitamin D 14079
08 Jun, 2018 17:58
admin Depression
1052 Hypothesis - Reduce insomnia with vitamin D 11909
13 Oct, 2010 21:55
admin Depression
537 Prisoners have very low vitamin D and get TB, influenza, and depression 9906
21 Dec, 2017 23:58
admin Deficiency of Vitamin D
Tuberculosis
Immunity
Depression
Shut-in
4658 First episode psychosis associated with a 33 percent lower vitamin D in 3 races – Sept 2013 9631
09 Dec, 2017 16:17
admin Depression
5082 Children with mental disorders have somewhat less vitamin D levels (graph) Jan 2014 9163
23 Feb, 2014 12:45
admin Depression
Cognitive
5252 Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014 9079
09 Oct, 2016 08:35
admin Depression
Meta-analysis of Vitamin D
Top news
4028 Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013 8789
29 Apr, 2013 20:21
admin Depression
Top news
Cognitive
3608 Suicide 2X more likely with low vitamin D (in military) – Jan 2013 8528
15 Aug, 2015 15:50
admin Depression
2439 Teens no longer depressed after vitamin D raised to 36 ng – Feb 2012 7689
02 May, 2018 19:17
admin Depression
Youth
4757 Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013 7585
18 Sep, 2017 17:15
admin Depression
Intervention
Top news
Injection
5731 Your health has a symbiotic relationship with 100 Trillion Bacteria – Mercola Aug 2014 7106
28 Aug, 2014 11:39
admin Depression
Antibiotics, probiotics
317 Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 7102
15 Jul, 2015 17:04
admin Deficiency of Vitamin D
Diabetes
Depression
5075 Serotonin regulated by Vitamin D – part 1 autism – Feb 2014 6542
26 Aug, 2017 13:16
admin Depression
Autism
838 An Exploratory Study of Postpartum Depression and Vitamin D - May 2010 6393
23 Jan, 2018 22:29
admin Pregnancy
Depression
Women
3066 Major depression associated with low vitamin D and low bone density – July 2012 6375
24 Jan, 2015 03:36
admin Bone - Health
Depression
Top news
3984 Low vitamin D and depression - Study and meta-analysis, April 2013 6094
19 Apr, 2015 17:13
admin Depression
Meta-analysis of Vitamin D
5274 Tricyclic antidepressants reduce the active but not the normally measured form of vitamin D in seniors – April 2014 6092
15 Sep, 2017 11:20
admin Depression
Top news

Pages listed in BOTH the categories Depression and Omega-3


In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.

A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment (“add-on” OR "adjunctive" OR "augmentation"). Meta-analyses, randomized controlled trials (RCTs) and non-randomized comparative studies that investigated the supplements as an add-on in the treatment of clinically diagnosed MDD were included. Agents had to be added to an existing antidepressant regime (augmentation) or started simultaneously with the antidepressant (acceleration). For n-3 PUFAs, folic acid and zinc, new meta-analyses were performed as part of this work.
Our meta-analyses of 10 articles on n-3 PUFAs and four on zinc support their efficacy. For folic acid, our meta-analysis does not support efficacy. For n-3 PUFAs, sensitivity analysis showed no difference between acceleration and augmentation designs, but significant differences between individuals with or without comorbidities. For the remaining substances, only a few RCTs were available. The preliminary data on inositol was negative, while one RCT for vitamin D demonstrated positive results. For vitamin B12 one and for SAMe two RCTs and a few open trials are available reporting positive and mixed results. To summarize, for most of the substances, the available data is not yet sufficient or inconclusive.

Created by admin. Last Modification: Wednesday November 22, 2017 03:00:42 UTC by admin. (Version 3)
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