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Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

European Neuropsychopharmacology, online 5 October 2017
Cora Schefft a, Laura L.Kilarski b. Tom Bschor c, Stephan Köhler
https://doi.org/10.1016/j.euroneuro.2017.07.004

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Vitamin D and Omega-3 have decreased a lot recent decades

Zinc and Vitamin D category has 90 items

20 Most-visited pages in Depression category in VitaminDWiki

	Id	Page	Hits	Last modification	Creator	Categories
	7681	Depression	332880	18 Nov, 2024 21:40	admin	Depression Category Associations
	14357	Post-partum depression and low Vitamin D - many studies	150527	03 Apr, 2024 12:34	admin	Pregnancy Depression
	7196	Seasonal Affective Disorder - treated by both vitamin D and bright light	130259	31 Aug, 2024 13:51	admin	Depression
	5777	Suicide associated with low vitamin D - many studies	50941	07 Apr, 2024 10:17	admin	Depression
	6247	ALL of the top 10 health problems of women are associated with low vitamin D	41753	01 Dec, 2022 21:39	admin	Cardiovascular Diabetes Health Cancer - Breast Depression Top news Cognitive Stroke Women
	3315	Hypothesis: Some Mental Illness could be treated or prevented with vitamin D	35390	29 Jan, 2021 19:56	admin	Depression Treatment by Vitamin D Top news
	7450	MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015	31123	08 Jan, 2023 14:03	admin	Bone - Health Breathing Pregnancy Diabetes Depression Vitamin D and Magnesium Parkinson Cystic Fibrosis Hypertension Stroke
	537	Prisoners have very low vitamin D and get TB, influenza, and depression	26082	11 Nov, 2019 18:39	admin	Deficiency of Vitamin D Tuberculosis Depression Shut-in Virus
	5252	Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014	24264	30 Apr, 2021 03:23	admin	Depression Meta-analysis of Vitamin D Top news
	5764	Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013	22629	14 Jun, 2016 02:26	admin	Depression Intervention
	4658	First episode psychosis associated with a 33 percent lower vitamin D in 3 races – Sept 2013	21850	09 Dec, 2017 16:17	admin	Depression
	4757	Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013	19393	18 Sep, 2017 17:15	admin	Depression Intervention Top news Injection
	5082	Children with mental disorders have somewhat less vitamin D levels (graph) Jan 2014	19212	23 Feb, 2014 12:45	admin	Depression Cognitive
	4028	Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013	18183	29 Apr, 2013 20:21	admin	Depression Top news Cognitive
	9679	Better Mental, Emotional and General health with better vitamin D – Oct 2017	16829	17 Mar, 2023 11:51	admin	Depression
	5274	Tricyclic antidepressants reduce the active but not the normally measured form of vitamin D in seniors – April 2014	16466	16 Oct, 2022 22:27	admin	Depression Top news
	1052	Hypothesis - Reduce insomnia with vitamin D	16297	13 Oct, 2010 21:55	admin	Depression
	3608	Suicide 2X more likely with low vitamin D (in military) – Jan 2013	15890	15 Aug, 2015 15:50	admin	Depression
	6789	Omega-3 prevents PTSD and some mood disorders - Aug 2015	15657	14 Sep, 2019 16:09	admin	Depression Vitamin D and Omega-3
	9577	Omega-3 and Vitamin D each treat many mental health problems - April 2018	14900	27 Sep, 2021 10:59	admin	Depression Autism Top news Cognitive Stroke Epilepsy ADHD Bipolar

Pages listed in BOTH the categories Depression and Omega-3

In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.

A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment (“add-on” OR "adjunctive" OR "augmentation"). Meta-analyses, randomized controlled trials (RCTs) and non-randomized comparative studies that investigated the supplements as an add-on in the treatment of clinically diagnosed MDD were included. Agents had to be added to an existing antidepressant regime (augmentation) or started simultaneously with the antidepressant (acceleration). For n-3 PUFAs, folic acid and zinc, new meta-analyses were performed as part of this work.
Our meta-analyses of 10 articles on n-3 PUFAs and four on zinc support their efficacy. For folic acid, our meta-analysis does not support efficacy. For n-3 PUFAs, sensitivity analysis showed no difference between acceleration and augmentation designs, but significant differences between individuals with or without comorbidities. For the remaining substances, only a few RCTs were available. The preliminary data on inositol was negative, while one RCT for vitamin D demonstrated positive results. For vitamin B12 one and for SAMe two RCTs and a few open trials are available reporting positive and mixed results. To summarize, for most of the substances, the available data is not yet sufficient or inconclusive.

Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

4060 visitors, last modified 22 Nov, 2017,

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- Behavior disorders reduced with Magnesium, Omega-3, and Zinc Manic depressives (Bipolar I) have low vitamin D levels – Jan 2018 Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019 Psychotic disorders not treated by Omega-3 when patents take anti-depressants and get therapy – June 2018 Depression in Nepalese 3.5 X more likely if low vitamin D – Sept 2018 Supplementation while pregnant and psychotic – 20 percent Omega-3, 6 percent Vitamin D – June 2016

This page is in the following categories (# of items in each category)

Depression 263 Meta-analysis of Vitamin D 649 Vitamin D and Omega-3 405 Zinc 89

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