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Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019

Serum 25-Hydroxyvitamin D Levels and Depression in Older Adults: A Dose-Response Meta-Analysis of Prospective Cohort Studies.

Am J Geriatr Psychiatry. 2019 Jun 5. pii: S1064-7481(19)30393-8. doi: 10.1016/j.jagp.2019.05.022.

VitaminDWiki

Intervention of Vitamin D for Depression


Meta-analyses of Vitamin D and Depression



Some pages listed in BOTH the categories Depression and Magnesium

Some pages listed in BOTH the categories Depression and Omega-3


Li H1, Sun D2, Wang A1, Pan H2, Feng W1, Ng CH3, Ungvari GS4, Tao L1, Li X5, Wang W6, Xiang YT7, Guo X8.

  • 1 Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.
  • 2 Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
  • 3 Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
  • 4 University of Notre Dame Australia, Fremantle, Australia; Division of Psychiatry, Medical School, University of Western Australia, Perth, Australia.
  • 5 Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia.
  • 6 Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Australia.
  • 7 Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. xyutly at gmail.com.
  • 8 Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. statguo at ccmu.edu.cn.


OBJECTIVE:
The association between serum vitamin D and risk of depression in older adults is controversial. We performed a dose-response meta-analysis of prospective cohort studies to examine the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and the risk of depression in older population.

METHODS:
Studies published before February 2018 in the PubMed, Cochrane Library, Web of Science, PsycINFO, and EMBASE databases were systematically searched. Prospective cohort studies that examined the association between serum 25(OH)D levels and the risk of depression in older adults were included. A random-effects model was used to calculate the pooled hazard ratio and the corresponding 95% confidence intervals. A nonlinear dose-response association was examined using restricted cubic spline functions.

RESULTS:
Six prospective studies covering 16,287 older adults with 1,157 cases of depression were included and analyzed. The pooled hazard ratio of depression for per 10-ng/mL increment in serum 25(OH)D was 0.88 (95% confidence intervals: 0.78-0.99, I2 = 79.0%, p <0.001 for heterogeneity). A linear dose-response association between serum 25(OH)D concentrations and incident depression was observed (p = 0.96 for nonlinearity).

CONCLUSION:
Serum 25(OH)D concentration is negatively associated with the risk of depression in older adults. This meta-analysis suggests that increasing 25(OH)D levels may be a useful approach to reduce the risk of depression in older adults and highlights the need for further large-scale clinical studies.

Created by admin. Last Modification: Friday July 19, 2019 17:10:43 GMT-0000 by admin. (Version 3)
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