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Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013

Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder.

Aust N Z J Psychiatry. 2013 Mar;47(3):271-5. doi: 10.1177/0004867412465022. Epub 2012 Oct 23.
Khoraminya N1, Tehrani-Doost M, Jazayeri S, Hosseini A, Djazayery A.

VitaminDWiki Summary and Comment

Less depression when Vitamin D added to Prozac
Expect that less Prozac would needed if add 1500 IU of vitamin D
Wonder if a lot of vitamin D would eliminate the need for Prozac
Would not have to wait for 4 weeks to get the Vitamin D beenfit if had used a loading dose to restore levels
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OBJECTIVE:
To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder.
METHODS:
In the present double-blind, randomized, placebo-controlled trial, 42 patients with a diagnosis of major depressive disorder based on DSM-IV criteria were randomly assigned into two groups to receive daily either 1500 IU vitamin D3 plus 20 mg fluoxetine or fluoxetine alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS) as a primary outcome measure and the 21-item Beck Depression Inventory (BDI) as a secondary outcome measure. Serum 25(OH) vitamin D was measured at baseline and after intervention.
RESULTS:
Forty patients completed the trial. A two-way repeated-measures analysis of variance showed that depression severity based on HDRS and BDI decreased significantly after intervention, with a significant difference between the two groups. The vitamin D + fluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment.
CONCLUSIONS:
In the present 8-week trial, the vitamin D + fluoxetine combination was superior to fluoxetine alone in controlling depressive symptoms.

PMID: 23093054
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