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Parkinson’s disease 2X more likely if low Vitamin D – meta-analysis May 2014

Vitamin D status and Parkinson’s disease: a systematic review and meta-analysis

Neurological Sciences, May 2014
Zheng Lv, Huiping Qi, Le Wang, Xiaoxue Fan, Fei Han, Hong Wang, Sheng Bi 13224510036 at 163.com
1. Department of Rehabilitation, the First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China
2. Department of Neurology, the Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, China
3. Department of Neurology, the First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China

To estimate the associations between vitamin D status and Parkinson’s disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: ‘vitamin D’ or ‘25(OH)D’ and ‘status’ or ‘deficiency’ or ‘insufficiency’ and ‘Parkinson’s disease’. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included.
Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), −16.9, 95 % confidence interval (CI)], −33.5 to −0.2).
Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1–2.0).
Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5–3.4). Low vitamin D levels are associated with an increased risk of PD.

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Overview Parkinsons and Vitamin D contains the following summary

Parkinson's Disease proven to be TREATED by Vitamin D (Many Meta-analyses of trials)


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