Vitamin D from different sources is inversely associated with Parkinson disease
Movement Disorders, Volume 30, Issue 4, pages 560–566, April 2015, DOI: 10.1002/mds.26117
Liyong Wang PhD1,2,*, Marian L. Evatt MD3, Lizmarie G. Maldonado MSPH1, William R. Perry MPH1, James C. Ritchie PhD4, Gary W. Beecham PhD1,2, Eden R. Martin PhD1,2, Jonathan L. Haines PhD5, Margaret A. Pericak-Vance PhD1,2, Jeffery M. Vance MD, PhD1,2 and William K. Scott PhD1,2 bscott at med.miami.edu
1John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA
2Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA
3Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
4Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
5Department of Epidemiology and Biostatistics, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography–tandem mass spectrometry in PD patients (n = 478) and controls (n = 431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles.
Vitamin D deficiency (total 25[OH]D < 20 ng/mL) and vitamin D insufficiency (total 25[OH]D < 30 ng/mL) are associated with PD risk (odds ratio [OR] = 2.6 [deficiency] and 2.1 [insufficiency]; P < 0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (Ptrend < 0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (Ptrend = 0.0008 and 0.12 in individuals with 25[OH]D3 < 20 ng/mL and 25[OH]D3 ≥ 20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients. © 2014 International Parkinson and Movement Disorder Society
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Risk of Parkinson disease associated with low vitamin D3 (2.6X) or low D2 – April 2015Printer Friendly Follow this page for updates9948 visitors, last modified 10 May, 2015, This page is in the following categories (# of items in each category)