Parkinson’s disease: Review of low-dose vitamin D RCTs found small benefit – Sept 2023

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Vitamin D in Parkinson’s disease: A systematic review of randomized controlled trials.

Clinical Nutrition Open Science Available online 28 September 2023 https://doi.org/10.1016/j.nutos.2023.09.005
Paraskevi Detopoulou 1 3, Gavriela Voulgaridou 2, Alexandra Saridaki 1 3, Ioanna Pylarinou 3, Elissaios- Minos Argyris 1, Vasilios Dedes 3, Constantinos Giaginis 4, Georgios I. Panoutsopoulos 3, Sousana K. Papadopoulou 2

In recent years, neurodegenerative diseases are a leading cause of morbidity and disability worldwide, with Parkinson's disease (PD) being the most prevalent. Although diet and vitamin status play a crucial role in PD, the results of vitamin D supplementation are scarce and contradictory. Therefore, the present systematic work reviewed the available randomized controlled trials (RCTs) regarding the role of vitamin D supplementation in patients with PD in the Pubmed, Scopus and Cochrane databases and in grey literature. Four RCTs including 321 patients with PD were identified. Various doses of vitamin D were administered (1,000- 10,000 IU/d) and different exposure outcomes were assessed. One study reported beneficial effects of vitamin D on the Hoehn and Yahr scale (HY) and two studies reported null effects on the Unified Parkinson's Disease Rating Scale (UPDRS). Regarding functional tests, heterogeneous results in the timed-up and go (TUG) test were observed in two studies. One study conducted minute walking tests at 6 and 10 minutes and found an improvement only in the 6MWT. In conclusion, a very small number of RCTs have assessed the effects of vitamin D supplementation on PD. Some isolated beneficial effects of vitamin D were reported on functional scales and tests but more studies are needed to draw safe conclusions regarding its supplementation in PD.
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VitaminDWiki - Overview Parkinson's and Vitamin D contains :

• Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
• Parkinson's category has 112 studies
• Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
• Parkinson patients: 60 % taking Vitamin D – Dec 2019
• Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
• Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
• 10 clinical trials for PD with vitamin D intervention as of June 2023
• Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
• Associated with PD are: Meta-analyses (12 ), Cognition (22 studies), Multiple Sclerosis (17 studies), VIRUS (4 studies), Omega-3 (3 studies), Vitamin D Receptor (11 studies)
• Note by the Founder of VitaminDWiki: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk

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VitaminDwiki – Comparing High-dose vitamin D therapies contains:

	Dr. Coimbra books 2018 2016	Dr. Somerville Optimal Dose	Dr. Gominak	Mr. Batcheller	Dr. Bredsen End of Alz.
Health problem	Multiple Sclerosis autoimmune, PD	sleep, flu, pain, obesity, etc.	Sleep	Cluster, Migraine Headaches	Alzheimer's Park. being added
Number of people (2019)	30,000 by 2022	5,000	5,000	8,000 (2023)	>1,000 ?
Vitamin D target	PTH is target typ: 150ng of D	100-140+ ng	60-80 ng	PTH is target typ: 80 ng of D	40-60 ng
Vitamin D daily dose (K = 1,000 IU)	20K - 200K 1,000 IU/kg	30K	2K + monthly test increasing dose until goal	4K - 40K 110 IU/kg	?
Omega-3 *	O-3	O-3	- - -	O-3	O-3
Magnesium *	Mg	Mg	- - -	Mg (400 mg)	-
Vitamin K2	K2 (no longer?)	K2	- - -	K2	-
Vitamin B...	B2, B9, B12	B3	B50-B100 3 months	B50	B12
Zinc *	Zn		- - -	Zn	-
Boron *?	B		- - -	B	-
Calcium Minimize rock-based Ca	Decrease Ca		- - -	Ca	-
Vitamin A avoid extremes	avoid A	avoid A	- - -	A	-
Other	Choline Selenium Co-Q 10		- - -	Co-Q 10	-
Loading dose Days instead of months	- - -	- - -	- - -	Loading "Cluster Balm"	-