Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022

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Vitamin D and Parkinson’s Disease - March 2022

Nutrients 2022, 14(6), 1220; https://doi.org/10.3390/nu14061220
by Antonia Pignolo 1ORCID,Sergio Mastrilli 1,Chiara Davì 1ORCID,Valentina Arnao 2,Paolo Aridon 1,Felipe Augusto dos Santos Mendes 3ORCID,Cesare Gagliardo 1ORCID andMarco D’Amelio 1,*
1 Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy
2 UO Neurologia e Stroke Unit, Azienda di Rilievo Nazionale ad Alta Specializzazione, Ospedali Civico Di Cristina Benfratelli, 90134 Palermo, Italy
3 Graduate Program in Rehabilitation Sciences, University of Brasília, Brasília 72220-275, Brazil

Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and indirectly modulates the expression of thousands of genes. Vitamin D is important for brain development, mature brain activity and associated with many neurological diseases, including Parkinson’s disease (PD). High frequency of vitamin D deficiency in patients with Parkinson’s disease compared to control population was noted nearly twenty years ago. This finding is of interest given vitamin D’s neuroprotective effect, exerted by the action of neurotrophic factors, regulation of nerve growth or through protection against cytotoxicity. Vitamin D deficiency seems to be related to disease severity and disease progression, evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn and Yahr (H&Y) scale, but not with age of PD onset and duration of disease. Additionally, fall risk has been associated with lower vitamin D levels in PD. However, while the association between vitamin D and motor-symptoms seems to be possible, results of studies investigating the association with non-motor symptoms are conflicting. In addition, very little evidence exists regarding the possibility to use vitamin D supplementation to reduce clinical manifestations and disability in patients with PD. However, considering the positive balance between potential benefits against its limited risks, vitamin D supplementation for PD patients will probably be considered in the near future, if further confirmed in clinical studies.
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Studies

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VitaminDWiki - Overview Parkinson's and Vitamin D contains

• Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
• Parkinson's category has 112 studies
• Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
• Parkinson patients: 60 % taking Vitamin D – Dec 2019
• Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
• Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
• 10 clinical trials for PD with vitamin D intervention as of June 2023
• Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
• Associated with PD are: Meta-analyses (12 ), Cognition (22 studies), Multiple Sclerosis (17 studies), VIRUS (4 studies), Omega-3 (3 studies), Vitamin D Receptor (11 studies)
• Note by the Founder of VitaminDWiki: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk

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VitaminDWiki - studies in both Parkinson's Disease and Vitamin D Receptor categories

This list is automatically updated

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VitaminDWiki - Meta-analyses of Parkinson's Disease

This list is automatically updated

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VitaminDWiki - additional supplements that have fought Parkinson's Disease

• Vitamin B12 and Parkinson’s Disease
• Omega-3 prevents Parkinson’s Disease – Review of RCT July 2019