Table of contents
- Vitamin D and Parkinson’s Disease - March 2022
- VitaminDWiki - Overview Parkinson's and Vitamin D contains
- VitaminDWiki - studies in both Parkinson's Disease and Vitamin D Receptor categories
- VitaminDWiki - Meta-analyses of Parkinson's Disease
- VitaminDWiki - additional supplements that have fought Parkinson's Disease
Vitamin D and Parkinson’s Disease - March 2022
Nutrients 2022, 14(6), 1220; https://doi.org/10.3390/nu14061220
by Antonia Pignolo 1ORCID,Sergio Mastrilli 1,Chiara Davì 1ORCID,Valentina Arnao 2,Paolo Aridon 1,Felipe Augusto dos Santos Mendes 3ORCID,Cesare Gagliardo 1ORCID andMarco D’Amelio 1,*
1 Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy
2 UO Neurologia e Stroke Unit, Azienda di Rilievo Nazionale ad Alta Specializzazione, Ospedali Civico Di Cristina Benfratelli, 90134 Palermo, Italy
3 Graduate Program in Rehabilitation Sciences, University of Brasília, Brasília 72220-275, Brazil
Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and indirectly modulates the expression of thousands of genes. Vitamin D is important for brain development, mature brain activity and associated with many neurological diseases, including Parkinson’s disease (PD). High frequency of vitamin D deficiency in patients with Parkinson’s disease compared to control population was noted nearly twenty years ago. This finding is of interest given vitamin D’s neuroprotective effect, exerted by the action of neurotrophic factors, regulation of nerve growth or through protection against cytotoxicity. Vitamin D deficiency seems to be related to disease severity and disease progression, evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn and Yahr (H&Y) scale, but not with age of PD onset and duration of disease. Additionally, fall risk has been associated with lower vitamin D levels in PD. However, while the association between vitamin D and motor-symptoms seems to be possible, results of studies investigating the association with non-motor symptoms are conflicting. In addition, very little evidence exists regarding the possibility to use vitamin D supplementation to reduce clinical manifestations and disability in patients with PD. However, considering the positive balance between potential benefits against its limited risks, vitamin D supplementation for PD patients will probably be considered in the near future, if further confirmed in clinical studies.
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Studies
VitaminDWiki - Overview Parkinson's and Vitamin D contains
- Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
- Parkinson's category has
117 studies - Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
- Parkinson patients: 60 % taking Vitamin D – Dec 2019
- Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
- Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
- 10 clinical trials for PD with vitamin D intervention as of June 2023
- Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
- Associated with PD are: Meta-analyses (
12 ), Cognition ( 24 studies), Multiple Sclerosis ( 18 studies), VIRUS ( 4 studies), Omega-3 ( 3 studies), Vitamin D Receptor ( 11 studies) - Note by the Founder of VitaminDWiki: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk
VitaminDWiki - studies in both Parkinson's Disease and Vitamin D Receptor categories
This list is automatically updated
- Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
- Parkinson’s Disease 3 X more likely if a poor Vitamin D Receptor – May – 2022
- Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Parkinson's disease cognitive decline associated with poor Vitamin D receptor – Nov 2016
- Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016
- Parkinson's Disease associations with Vitamin D Receptor and GC gene – June 2016
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
VitaminDWiki - Meta-analyses of Parkinson's Disease
This list is automatically updated
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Parkinson’s patients 50X less likely to get even a little sun– meta-analysis Jan 2019
- Parkinson's Disease 2.1 X more likely if low Vitamin D – Meta-analysis Nov 2018
- Parkinson’s Disease systematic review finds association with low vitamin D – Jan 2016
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Parkinson’s Disease – no association found with changes in Vitamin D genes – meta-analysis June 2014
- Parkinson’s disease 2X more likely if low Vitamin D – meta-analysis May 2014
- Parkinson’s Disease and the “Sunshine” Vitamin (vitamin D) – July 2013
- Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013
- Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012
VitaminDWiki - additional supplements that have fought Parkinson's Disease
Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 20223900 visitors, last modified 15 Mar, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 17230 PD 2022 T3.jpg admin 14 Mar, 2022 535.30 Kb 296 17229 PD 2022 T2.jpg admin 14 Mar, 2022 503.75 Kb 329 17228 PD 2022 T1.jpg admin 14 Mar, 2022 296.01 Kb 309 17226 PD Vit D March 2022.pdf admin 14 Mar, 2022 771.46 Kb 412