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Parkinson’s – Vitamin D, bone density, insomnia, falls, poor sleep, anxiety – March 2019

Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson’s disease symptoms

Nutrients 2022,14, 1220. https://doi.org/10.1111/ane
Hui-Jun Zhang, Jin-Ru Zhang, Cheng-Jie Mao, Kai Li, Fen Wang, Jing Chen, Chun-Feng Liu

Vitamin D deficiency is widespread in patients with Parkinson's disease (PD). Our aim was to determine whether serum vitamin D levels correlated with bone mineral density (BMD) and non-motor symptoms in patients with PD.

Materials & Methods
A consecutive series of 182 patients with PD and 185 healthy controls were included. Serum 25-hydroxyvitamin D (25OHD) levels were measured by immunoassay, while BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Associations between serum vitamin D levels and clinical data were evaluated using partial correlation analysis.

Patients with PD had significantly lower serum 25(OH)D levels relative to healthy controls (49.75 ± 14.11 vs 43.40 ± 16.51, P < 0.001). Furthermore, PD patients with lower vitamin D levels had a significantly higher frequency of falls (P = 0.033) and insomnia (P = 0.015). They also had significantly higher scores for the Pittsburgh Sleep Quality Index (PSQI; P = 0.014), depression (P = 0.020), and anxiety (P = 0.009).
Finally, patients with PD also had a significantly

  • lower mean BMD of the lumbar spine (P = 0.011) and femoral neck (P < 0.001).

After adjusting for age, sex, and body mass index, vitamin D levels significantly correlated with

  • falls,
  • insomnia, and
  • scores for the PSQI, depression, and anxiety.

In patients with PD, vitamin D levels significantly correlated with falls and some non-motor symptoms. However, no associations were found between BMD and the serum 25(OH)D levels in patients with PD. Thus, vitamin D supplementation is a potential therapeutic for non-motor PD symptoms.
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VitaminDWiki - Overview Parkinson's and Vitamin D contains

VitaminDWiki – Sleep category contains

96 items in sleep category

A few items in SLEEP category

VitaminDWiki – Falls and Fractures category contains



14+ VitaminDWiki pages have ANXIETY in the title

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Items found: 14
Title Modified
Half as much anxiety and sleep problems if get lots of vitamin D from food (excluded getting D from supplements) – Feb 2024 23 Feb, 2024
Anxiety, Vitamin D, Omega-3 - many studies 23 Feb, 2024
Low Vitamin D is associated with risk of Depression 5X, Stress 4.8 X, and Anxiety 3.9 X (Saudi Arabia college students) – July 2023 29 Jul, 2023
Parkinson’s – Vitamin D, bone density, insomnia, falls, poor sleep, anxiety – March 2019 10 May, 2023
Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022 22 Dec, 2022
Depression and Anxiety treatment with Vitamin D - probable molecular pathways - June 2022 21 Dec, 2022
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022 07 Oct, 2022
Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022 29 May, 2022
General Anxiety Disorder treated by weekly Vitamin D (50,000 IU -Omega-3, Mg also help) – Sept 2019 09 Dec, 2019
Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018 02 Sep, 2019
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018 10 Nov, 2018
Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018 19 Sep, 2018
Why is teen anxiety increasing so much (no mention of Magnesium, Vitamin D nor Omega-3) – Oct 2017 11 Oct, 2017
Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014 11 Feb, 2015

Attached files

ID Name Comment Uploaded Size Downloads
19556 PD March 2019.pdf admin 10 May, 2023 532.27 Kb 54