Cognitive impairment 5 percent less likely for each ng more of Vitamin D (Parkinson’s) – May 2022

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Correlation between serum 25(OH)D and cognitive impairment in Parkinson's disease

J Clin Neurosci . 2022 Apr 27;100:192-195. doi: 10.1016/j.jocn.2022.04.015 PDF behind paywall
Han Wu 1, Hafiz Khuram Raza 1, Zhen Li 1, Zeheng Li 1, Jie Zu 1, Chuanying Xu 1, Di Yang 1, Guiyun Cui 2

This study aimed to investigate the relationship between serum 25(OH)D and cognitive impairment in patients with Parkinson's disease (PD), hoping to provide possible ideas for the diagnosis and prevention of PD with cognitive impairment. Vitamin D is a neurosteroid with neurotrophic and neuroprotective functions, playing an important role in PD and its progression. In the present study, serum 25(OH)D levels were significantly decreased in PD patients (45.86 ± 14.81 nmol/L) compared to healthy controls(56.54 ± 14.00 nmol/L) (P < 0.001), and significant differences were also observed in PD patients with normal cognition (PD-NC), PD patients with mild cognitive impairment (PD-MCI) and PD patients with dementia (PDD)(P < 0.05). Moreover, there was a positive correlation between serum 25(OH)D levels and Montreal cognitive assessment(MoCA) scores (r = 0.489,P < 0.001).
The increased serum 25(OH)D was an independent protective factor of cognitive impairment in PD (OR = 0. 949, P = 0.005), and the sensitivity, specificity, and AUC under the ROC curve area of serum 25(OH)D were 53.3%, 86.5%, and 0.713, respectively. These findings support the relationship between cognitive impairment and Vitamin D in PD patients. Serum 25(OH)D may be a useful biomarker for diagnosing cognitive impairment in patients with PD.

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VitaminDWiki - Cognitive contains

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

348 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (6 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (48 studies), Intervention (18 studies), Meta-analyses (21 studies), Depression (21 studies), Parkinson's (19 studies),  Click here for details

Dementia is associated with low vitamin D - many studies 50+
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

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VitaminDWiki - Overview Parkinson's and Vitamin D contains

• Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
• Parkinson's disease stabilized with just 1200 IU of vitamin D – RCT May 2013
  First RCT to report results - +anticipate far better results when more vitamin D is used.
     (Belief based on the results with vitamin D on MS and Diabetes)
  Additonal proofs that vitamin D treats or prevents diseases
• 7 clinical trials for PD with vitamin D intervention as of June 2022
• Parkinson patients: 60 pcnt taking Vitamin D – Dec 2019
• Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
• VitaminDWiki interview and transcript - Jan 2022 30 topics discussed
• Low Vitamin D increases Parkinson's by 3X– July 2010 only a 30 year test, need more study
• Associated with PD are: Meta-analyses (12 ), Cognition (19 studies), Multiple Sclerosis (13 studies), VIRUS (4 studies), Omega-3 (2 studies), Vitamin D Receptor (10 studies)
•    Parkinson's category has 101 items

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