Afr Health Sci. 2015 Jun;15(2):523-31. doi: 10.4314/ahs.v15i2.27.
Mutlu N1, Esra H1, Begum A2, Fatma D3, Arzu Y4, Yalcin H5, Fatih K5, Selahattin K6.
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
2Department of Obstetrics and Gynecology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.
3Department of Endocrinology and Metabolism, Ministry of Health's Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
4Department of Obstetrics and Gynecology, Ministry of Health's Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey.
5Department of Internal Medicine, Ministry of Health's Istanbul Education and Research Hospital, Istanbul, Turkey.
6Department of Obstetrics and Gynecology, Ministry of Health's Antalya Education and Research Hospital, Antalya, Turkey.
To investigate the relationship between maternal vitamin D status and glucose intolerance, and its impact on pregnant women and their newborns.
A cohort of pregnant women were divided into three groups: women with gestational diabetes mellitus, ones with normal results both after the 50 gr and 100 gr OGTT (CG-1) and ones having a positive result after the 50 gr OGTT screening but negative results for gestational diabetes mellitus (GDM) after the 100 gr OGTT (CG-2).
The newborn length in CG-1 was greater than in GDM and CG-2 (p= 0.002 and p= 0.02). Fasting blood glucose and insulin resistance (IR) were negatively correlated with length of the newborns (r=-0.3, p=0.03 and r=-0.3, p=0.01). The newborns of women with GDM had lower APGAR-1 and 5 scores than those of CG-1 and CG-2 (APGAR-1 p= 0.001 and p= 0.004, APGAR-5 p=0.005 and p=0.007, respectively). APGAR scores were correlated negatively with IR (APGAR-1 r=-0.32, p=0.01, APGAR-5 r=-0.3, p=0.03) and positively with 25OHD levels (APGAR-1 r=0.3, p=0.01, APGAR-5 r=0.3, p=0.02).
Vitamin D deficiency, gestational diabetes and insulin resistance are interrelated. Severe vitamin D deficiency during pregnancy is associated with poor pregnancy and neonatal outcome.
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