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Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018

In utero exposure to extra vitamin D from food fortification and the risk of subsequent development of gestational diabetes: the D-tect study.

Nutr J. 2018 Nov 2;17(1):100. doi: 10.1186/s12937-018-0403-5.
Keller A1, Stougård M2, Frederiksen P2, Thorsteinsdottir F2, Vaag A3, Damm P4,5, Jacobsen R2,6, L Heitmann B2,7,8,9.


Margerine fortification with 50 IU of Vitamin D/100 grams was stopped in Denmark in June 1985. This study compared subsequent GD in the women born before and after that change

Change of Vitamin D Fortification in Denmark

Pages listed in BOTH of the categories Diabetes and Pregnancy

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The primary aim of this study was to assess whether exposure during fetal life to extra vitamin D from food fortification was associated with a reduction in the risk of subsequently developing gestational diabetes mellitus (GDM). Furthermore, we examined whether the effect of the vitamin D from fortification differed by women's season of birth.

This semi-ecological study is based on the cancellation in 1985 of the mandatory policy to fortify margarine with vitamin D in Denmark, with inclusion of entire national adjacent birth cohorts either exposed or unexposed to extra vitamin D in utero. The identification of GDM cases later in life among both exposure groups was based on the Danish national health registers. Logistic regression analyses generating odds ratios (ORs) and 95% confidence intervals (95% CIs) were performed.

Women who were prenatally exposed to the extra vitamin D from fortification tended to have a lower risk of subsequently developing GDM than unexposed women (OR 0.87, 95%CI 0.74,1.02, P = 0.08). When analyses were stratified by women's season of birth, exposed women born in spring had a lower risk of developing GDM compared to unexposed subjects (OR 0.68, 95%CI 0.50,0.94, p = 0.02).

This study suggests that prenatal exposure to extra vitamin D from mandatory fortification may lower the risk of developing gestational diabetes among spring-born women.

TRIAL REGISTRATION: This study is part of the D-tect project, which is registered on clinicaltrials.gov: NCT03330301 .

Created by admin. Last Modification: Sunday November 24, 2019 19:39:56 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12129 GD 50 IU.pdf PDF 2018 admin 14 Jun, 2019 15:09 401.24 Kb 458