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Vitamin D is a biomarker for autoimmune, neurological and psychiatric diseases - Jan 2022


Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases

Diagnostics 2022, 12, 130. https:// doi.org/ 10.3390/diagnostics12010130

Autoimmune
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Depression Schizophrenia
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Giulia Bivona , Caterina Maria Gambino 1,+, Bruna Lo Sasso 1, Concetta Scazzone 1, Rosaria Vincenza Giglio 1, Luisa Agnello 1 and Marcello Ciaccio 1,2/*
Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, Italy; giulia.bivona at unipa.it (G.B.); cmgambino at libero.it (C.M.G.); bruna.losasso at unipa.it (B.L.S.); concetta.scazzone at unipa.it (C.S.); giglio.rosaria.vincenza at gmail.com (R.V.G.); luisa.agnello at unipa.it (L.A.)
Department of Laboratory Medicine, University Hospital "P Giaccone", 90127 Palermo, Italy * Correspondence: marcello.ciaccio at unipa.it; Tel.: +39-0916553296

Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, metaanalyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegeneration, mental illness and immune-mediated disorders. The lack of standardized data, as well as discrepancies among the studies (in the analytical methods, cut-offs, endpoints and study sets), weakened the findings achieved, hindered pooling data, and, consequently, hampered drawing conclusions. This narrative review summarizes the main findings from the studies performed on serum 25(OH)D in neurological, psychiatric and autoimmune diseases, and clarifies whether or not serum 25(OH)D can be used as a reliable biomarker in these diseases.
 Download the PDF from VitaminDWiki

A biomarker is used to identify, monitor and predict treatment responses

VitaminDWiki - Autoimmune category


VitaminDWiki - Autoimmune Diseases and Vitamin D Receptor (Restricts D to cells)

VitaminDWiki - Overview MS and vitamin D contains:

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.


VitaminDWiki - Depression summary


VitaminDWiki - Intervention of Vitamin D for Depression

VitaminDWiki - Meta-analyses of Vitamin D and Depression

VitaminDWiki - Depression and Vitamin D Receptor

VitaminDWiki - Rheumatoid Arthritis category

107 RA items     See also Overview Rheumatoid Arthritis   Autoimmune  Inflammation   Pain - Chronic

    Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D

RA and Vitamin D Receptor (auto-updated)

RA Treated by Vitamin D


VitaminDWiki - Overview Schizophrenia and Vitamin D contains

Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored


Created by admin. Last Modification: Tuesday February 1, 2022 00:55:12 GMT-0000 by admin. (Version 10)

Attached files

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16974 MDD2.jpg admin 01 Feb, 2022 00:30 159.53 Kb 94
16973 MDD1.jpg admin 01 Feb, 2022 00:30 155.63 Kb 100
16972 Auto3.jpg admin 01 Feb, 2022 00:19 146.49 Kb 94
16971 Auto2.jpg admin 01 Feb, 2022 00:19 133.78 Kb 98
16970 Auto1.jpg admin 01 Feb, 2022 00:19 156.89 Kb 100
16969 Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases.pdf PDF 2022 admin 01 Feb, 2022 00:10 769.44 Kb 57
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