Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: “The COMORA Study”
International Journal of Rheumatology. Volume 2017 (2017), Article ID 5491676, 8 pages. https://doi.org/10.1155/2017/5491676
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Argentina, Austria, Egypt, France, Germany, Hungary, Italy, Korea, Morocco, Netherlands, Spain, Taiwan, UK, Uruguay, USA
Najia Hajjaj-Hassouni,1,2,3 Nada Mawani,1,2 Fadoua Allali,1,2 Hanan Rkain,1,2,4 Kenza Hassouni,5 Ihsane Hmamouchi,1,2 and Maxime Dougados6
- 1LIRPOS-URAC30, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
- 2Department of Rheumatology, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Salé, Morocco
- 3Innovation Center, Mohammed VI University for Health Sciences, Casablanca, Morocco
- 4Department of Physiology, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
- 5International School for Public Health, Mohammed VI University for Health Sciences, Casablanca, Morocco
- 6Department of Rheumatology, Hôpital Cochin, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, EULAR Center of Excellence, INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France
Correspondence should be addressed to Najia Hajjaj-Hassouni
The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients’ RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 0.1–151.
Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients.
43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency (). Finally, our study shows that the status of low levels of vitamin D is common in RA in different countries and under different latitudes. Absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency. Low levels of vitamin D were associated with patients characteristics (age, BMI, and educational level), RA (disease activity and corticosteroid dosage), and comorbidities (lung disease and osteoporosis therapy). This suggests the need for a particular therapeutic strategy to improve vitamin D status in RA patients.
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