Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
PLoS One. 2016 Jan 11;11(1):e0146351. doi: 10.1371/journal.pone.0146351. eCollection 2016.
Lin J1, Liu J1, Davies ML2, Chen W1.
1 Department of Rheumatology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
2 Clinical Immunology Laboratory, Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America.
- Overview Rheumatoid Arthritis and vitamin D
- Every patient with rheumatoid arthritis had low vitamin D, severity was proportional to degree of deficiency – June 2014
The Meta-analysis of Rheumatoid Artritis and Vitamin D
- Rheumatoid Arthritis pain is reduced by Vitamin D, high doses also reduced inflammation (CRP) – Meta-analysis July 2023
- Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018
- Rheumatic diseases not helped by Vitamin D – if you ignore what and how much was given – meta-analysis June 2017
- Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
- Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Juvenile Rheumatoid Arthritis associated with low vitamin D, but how low – meta-analysis Jan 2013
- Rheumatoid arthritis 24 percent more likely if low vitamin D consumption– meta-analysis Sept 2012
Intervention AND Rheumatoid Arthritis
- Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Just 500 IU of vitamin D helped reduce rheumatoid arthritis pain - RCT Oct 2011
BACKGROUND:
The evidence from epidemiological studies concerning the relationship between serum vitamin D concentrations and rheumatoid arthritis (RA) is inconsistent. This meta-analysis is aimed at determining the magnitude of the correlation between this common autoimmune disease and vitamin D, an important nutrient known to dampen adaptive immune responses.
METHODS:
Through multiple search strategies, relevant literature was identified and evaluated for quality before May 16 2015. Data extracted from eligible studies was synthesized to calculate pooled correlation coefficient (r), mean difference (MD) and odds ratio (OR). The Venice criteria were applied to assess the credibility of the evidence for each statistically significant association.
RESULTS:
A total of 24 reports involving 3489 patients were selected for analysis. RA patients had lower vitamin D levels than healthy controls (MD:-16.52 nmol/L, 95% confidence intervals CI:-18.85 to -14.19 nmol/L). There existed a negative relationship between serum 25-hydroxyvitamin D (25OHD) level and disease activity index, e.g. 25OHD vs. Disease Activity Score in 28 joints (DAS28): r = -0.13, 95% CI -0.16 to -0.09; 25OHD vs. C-reactive protein: r = -0.12, 95% CI -0.23 to -0.00. Additionally, latitude-stratified subgroup analysis yielded a relatively stronger negative correlation between 25OHD and DAS28 in low-latitude areas. This inverse relationship also appeared more significant in developing countries than in developed countries. No publication bias was detected.
CONCLUSION:
RA patients had lower vitamin D values than healthy controls. There was a negative association between serum vitamin D and RA disease activity. However, more strictly controlled studies are needed to validate these findings.
One of many Forest Plots in the PDF
PMID: 26751969