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Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016

Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis.

Clin Exp Rheumatol. 2016 Apr 6. [Epub ahead of print]
Lee YH1, Bae SC2.
1Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. lyhcgh at korea.ac.kr.
2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

This study aimed to evaluate the relationship between the 25-hydroxyvitamin D [25(OH)D] level and rheumatoid arthritis (RA) and the correlation between serum vitamin D level and RA activity.
We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and prevalence of vitamin D deficiency in patients with RA compared to healthy controls and the correlation coefficients between the vitamin D level and disease activity score 28 (DAS28) in RA patients.
Fifteen studies that included a total of 1,143 RA patients and 963 controls were available for this meta-analysis. The meta-analysis showed that the serum vitamin D level in the RA group was significantly lower than that in the control group (SMD=-0.608, 95% CI=-1.105-[-0.017], p=0.017). In addition, the prevalence of vitamin D deficiency was significantly higher in the RA group than in the control group (55.2% vs. 33.2%; OR = 2.460, 95% CI = 1.135-5.332, p=0.023). Thirteen studies evaluated the correlation between the vitamin D level and its activity in 924 RA patients. Meta-analysis showed a significant inverse correlation between the vitamin D level and DAS28 (Correlation coefficient =-0.278, 95% CI =-0.393-[-0.153], p=1.8 x 10-5).
Our meta-analysis demonstrates that serum vitamin D level is significantly low in patients with RA, vitamin D deficiency is prevalent in RA patients compared to controls, and the vitamin D level correlates inversely with RA activity. Our meta-analysis suggests that the vitamin D level is associated with susceptibility to RA and RA activity.

PMID: 27049238  Download the PDF from VitaminDWiki

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The Meta-analysis of Rheumatoid Arthritis and Vitamin D