Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer
Saudi Journal of Biological Sciences, https://doi.org/10.1016/j.sjbs.2020.01.006
Ayat B.Al-GhafariabcKhadijah S.Balamasha1Huda A.Al Doghaithera2
Note: Several Cancers have "learned" how to protect themselves from Vitamin D
After the cancer starts, it decreases the Vitamin D Receptor activation.
Thus for some cancers: Cancer ==> poor VDR, rather than poor VDR ==> Cancer
Vitamin D Receptor category with CANCER in the title (76 as of Feb 2022)
This list is automatically updated
See also on web
- Colorectal Cancer increased 6X for one form of Receptor problem - Sept 2020 PDF
- TaqI and ApaI Variants of Vitamin D Receptor Gene Increase the Risk of Colorectal Cancer in a Saudi Population
- Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Download the PDF from VitaminDWiki
Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity worldwide, and there has been a significant increase in the incidence of CRC in recent decades. Therefore, there is an urgent need to identify blood biomarkers that can be used for early diagnosis. It is not yet clear whether the level of vitamin D and its receptor, vitamin D receptor (VDR), in the blood are helpful factors in the diagnosis of CRC. Therefore, the study focuses on determining the VDR serum level’s contribution and other chemical parameters to the risk of CRC. A total of 189 Saudi participants (66 CRC patients and 123 control patients) aged 20-80 years old were enrolled in this case-control study. A serum sample was collected from each participant, and the levels of VDR and other bone profile tests were determined using ELISA or chemiluminescent assays. P values < 0.05 were considered statistically significant. The results showed a highly significant reduction in the levels of total vitamin D (P < 0.0001), VDR (P < 0.0001), vitamin D3 (P < 0.05), and calcium (P < 0.0001) in the serum of CRC patients compared to the controls. However, the alkaline phosphatase level was higher in CRC patients compared to the controls (P < 0.0001). None of the blood markers showed a significant correlation to the progression of CRC (P > 0.05). More investigation is needed to elucidate different physiological processes that can be affected by these blood biomarkers, therefore changing the carcinogenesis of CRC.