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No Preeclampsia during pregnancy if more than 60 ng of vitamin D – RCT July 2013

From Grassroots Health Newsletter March 2017


What effect might vitamin D have on hypertensive disorders during pregnancy?

Data from two clinical trials demonstrate a reduction in hypertensive pregnancy disorders with an increased vitamin D level (Wagner CL et al., Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis. J Steroid Biochem Mol Biol. 2013 Jul;136:313-20.).

Among 505 pregnant women, there was a 56% reduction in risk of a hypertensive disorder at 40 ng/ml and a 65% risk reduction at 50 ng/ml.

  • 22 participants (4%) were diagnosed with a hypertensive pregnancy disorder; 18 were diagnosed with hypertension and 5 were diagnosed with preeclampsia (1 was diagnosed with both).
  • Among those diagnosed with a hypertensive pregnancy disorder, 73% had final 25(OH)D values below 40 ng/ml.
  • For preeclampsia specifically, all five were below 40 ng/ml.
  • There were no cases of hypertensive disorders among women with vitamin D serum levels above 60 ng/ml.

VDW# = 8330


VitaminDWiki pages containing PREECLAMPSIA in title

Items found: 47
Title Modified
No Preeclampsia during pregnancy if more than 60 ng of vitamin D – RCT July 2013 02 Jul, 2021
Child 49 percent higher risk of being overweight if preeclampsia during pregnancy – Sept 2017 02 Jul, 2021
Hypertension in pregnancy (preeclampsia) more frequent in winter (low vitamin D) – Jan 2015 22 Jun, 2021
Preeclampsia (hypertension while pregnant) varies with season (O.R. 0.57) – June 2021 22 Jun, 2021
Preeclampsia (low vitamin D) doubles the risk of later cardiovascular problems – Sept 2019 07 Oct, 2019
Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019 29 Sep, 2019
Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 12 Sep, 2019
Preeclampsia 2.7 X less likely if 50,000 IU of Vitamin D every 2 weeks – meta-analysis Sept 2019 06 Sep, 2019
Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019 23 Apr, 2019
Preeclampsia 3X more likely if low vitamin D at 25th week – April 2012 20 Feb, 2019
Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013 20 Feb, 2019
Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014 20 Feb, 2019
Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018 20 Feb, 2019
Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017 20 Feb, 2019
Preeclampsia is not reduced by vitamin D (if you ignore vitamin D level, dose size, frequency and duration) – July 2017 20 Feb, 2019
Preeclampsia inversely proportional to serum Magnesium – Oct 2014 20 Feb, 2019
Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016 20 Feb, 2019
Preeclampsia reduced 1.7 X by aspirin (but reduced 7 X by Vitamin D) – Feb 2018 22 Aug, 2018
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017 24 Oct, 2017
Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017 08 Sep, 2017
Risk of preeclampsia might be cut in half if take an amount of Vitamin D – meta-analysis Sept 2017 04 Sep, 2017
Preeclampsia reoccurred half as often if get 50,000 IU of Vitamin D every two weeks – Aug 2017 22 Aug, 2017
Dark-skined mothers: preeclampsia 12X more likely if gestational hypertension – May 2014 17 Aug, 2017
Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017 17 Jul, 2017
Preeclampsia doubles the risk of mild cognitive impairment – July 2017 05 Jul, 2017
Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016 18 Dec, 2016
Preeclampsia 3.5 times more likely if low vitamin D (affects 348 Vit. D genes) – RCT Nov 2016 15 Nov, 2016
Preeclampsia 4X less likely if vitamin D levels increased by 8 ng during pregnancy – March 2016 05 Apr, 2016
Preeclampsia 2X more likely if low vitamin D, unless adjust for vitamin D factors (BMI, skin color) – Dec 2015 21 Jan, 2016
2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013 16 Jan, 2016
Preeclampsia and eclampsia associated with lower vitamin D, etc. – Sept 2015 13 Nov, 2015
Preeclampsia increased risk of Congenital Heart Defects by 60 percent (vitamin D not mentioned) Oct 2015 28 Oct, 2015
5,000 IU Vitamin D was not enough to reduce preeclampsia but did help future infant – RCT April 2014 15 Oct, 2015
Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015 15 Oct, 2015
Why preeclampsia is 5X more likely if vitamin D insufficient – Jan 2015 06 Sep, 2015
Preeclampsia – hypothesis as to why vitamin D helps – June 2015 09 Jun, 2015
Preeclampsia was prevented or treated by vitamin D in majority of studies – review May 2015 26 May, 2015
Women with low vitamin D 4X more likely to have preeclampsia in pregnancy – Nov 2010 28 Mar, 2015
7X increase in early severe preeclampsia associated with low vitamin D – Aug 2012 20 Mar, 2015
High blood pressure during pregnancy (preeclampsia) associated with low vitamin D, c-section – Jan 2015 22 Jan, 2015
Preeclampsia 40 percent less likely if had more than 20 ng of vitamin D – Jan 2014 30 Jan, 2014
Preeclampsia 40 percent less likely if mother had more than 20 ng of vitamin D – Jan 2014 30 Jan, 2014
2X more likely to have preeclampsia if less than 20 ng of vitamin D – Meta-analysis Jan 2013 11 Jan, 2014
Almost 3X more likely to get preeclampsia if low vitamin D and high PTH– July 2013 15 Sep, 2013
How to reduce preeclampsia - May 2011 19 Apr, 2013
Low vitamin D results in severe preeclampsia and low birth weight – Mar 2011 27 Nov, 2011
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