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During pregnancy even 400 IU helps metabolic status – RCT July 2013

Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women.

J Nutr. 2013 Jul 24. (text is behind a paywall)
Asemi Z, Samimi M, Tabassi Z, Shakeri H, Esmaillzadeh A.
Research Center for Biochemistry and Nutrition in Metabolic Diseases and.

Unfavorable metabolic profiles and oxidative stress in pregnancy are associated with several complications. This study was conducted to determine the effects of vitamin D supplementation on serum concentrations of high-sensitivity C-reactive protein (hs-CRP), metabolic profiles, and biomarkers of oxidative stress in healthy pregnant women.

This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 pregnant women aged 18-40 y old at 25 wk of gestation. Participants were randomly assigned to receive either 400 IU/d cholecalciferol supplements (n = 24) or placebo (n = 24) for 9 wk. Fasting blood samples were taken at study baseline and after 9 wk of intervention to quantify serum concentrations of hs-CRP, lipid concentrations, insulin, and biomarkers of oxidative stress. After 9 wk of intervention, the increases in

  • serum 25-hydroxyvitamin D and calcium concentrations were greater in the vitamin D group (+3.7 μg/L and +0.20 mg/dL, respectively) than in the placebo group (-1.2 μg/L and -0.12 mg/dL, respectively; P < 0.001 for both).
  • Vitamin D supplementation resulted in a significant decrease in serum hs-CRP (vitamin D vs. placebo groups: -1.41 vs. +1.50 μg/mL; P-interaction = 0.01) and
  • insulin concentrations (vitamin D vs. placebo groups: -1.0 vs. +2.6 μIU/mL; P-interaction = 0.04) and a significant increase in the
  • Quantitative Insulin Sensitivity Check Index score (vitamin D vs. placebo groups: +0.02 vs. -0.02; P-interaction = 0.006),
  • plasma total antioxidant capacity (vitamin D vs. placebo groups: +152 vs. -20 mmol/L; P-interaction = 0.002), and
  • total glutathione concentrations (vitamin D vs. placebo groups: +205 vs. -32 μmol/L; P-interaction = 0.02) compared with placebo.
  • Intake of vitamin D supplements led to a significant decrease in fasting plasma glucose (vitamin D vs. placebo groups: -0.65 vs. -0.12 mmol/L; P-interaction = 0.01),
  • systolic blood pressure (vitamin D vs. placebo groups: -0.2 vs. +5.5 mm Hg; P-interaction = 0.01), and
  • diastolic blood pressure (vitamin D vs. placebo groups: -0.4 vs. +3.1 mm Hg; P-interaction = 0.01) compared with placebo.

In conclusion, vitamin D supplementation for 9 wk among pregnant women has beneficial effects on metabolic status.

PMID: 23884390


Changes relative to placebo - formatted by VitaminDWiki

Vitamin D +12 ng/ml
Calcium +0.32 mg/dL
Serum hs-CRP -1.4 μg/mL
insulin concentrations -3.6 μIU/mL
Quantitative Insulin Sensitivity Check
Index score
+0.04
plasma total antioxidant capacity +172 mmol/L
total glutathione concentrations +237 μmol/L
fasting plasma glucose -0.53 mmol/L
systolic blood pressure -5.7 mm Hg
diastolic blood pressure -3.5 mm Hg

We can only imagine the great changes from 4,000 IU instead of just 400 IU

See also VitaminDWiki

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