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Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017

Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis.

Nutrients. 2017 Oct 18;9(10). pii: E1141. doi: 10.3390/nu9101141.
Khaing W1,2, Vallibhakara SA3, Tantrakul V4, Vallibhakara O5, Rattanasiri S6, McEvoy M7, Attia J8, Thakkinstian A9


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As with virtually all other meta-analyses, the dose sizes were ignored.
Vitamin D charts from GrassrootsHealth - May 2016 has the following chart
Pages listed in BOTH the categories Pregnancy and Hypertension (preeclampsia)

Vitamin D supplementation effects with or without calcium in pregnancy for reducing risk of preeclampsia and gestational or pregnancy induced hypertension are controversial. Literature was systematically searched in Medline, Scopus and Cochrane databases from inception to July 2017. Only randomized controlled trials (RCTs) in English were selected if they had any pair of interventions (calcium, vitamin D, both, or placebo). Systematic review with two-step network-meta-analysis was used to indirectly estimate supplementary effects.
Twenty-seven RCTs with 28,000 women were eligible. A direct meta-analysis suggested that calcium, vitamin D, and calcium plus vitamin D could lower risk of preeclampsia when compared to placebo with the pooled risk ratios (RRs) of 0.54 (0.41, 0.70), 0.47 (0.24, 0.89) and 0.50 (0.32, 0.78), respectively.
Results of network meta-analysis were similar with the corresponding RRs of 0.49 (0.35, 0.69), 0.43 (0.17, 1.11), and 0.57 (0.30, 1.10), respectively. None of the controls were significant. Efficacy of supplementation, which was ranked by surface under cumulative ranking probabilities, were: vitamin D (47.4%), calcium (31.6%) and calcium plus vitamin D (19.6%), respectively. Calcium supplementation may be used for prevention for preeclampsia. Vitamin D might also worked well but further large scale RCTs are warranted to confirm our findings.

PMID: 29057843 DOI: 10.3390/nu9101141

Created by admin. Last Modification: Wednesday November 22, 2017 02:58:42 GMT-0000 by admin. (Version 4)

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8582 Preeclampsia Vitamin D and Ca.pdf admin 24 Oct, 2017 769.71 Kb 700