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Hypertension in pregnancy (preeclampsia) more frequent in winter (low vitamin D) – Jan 2015

[177-POS]: Seasonality of pregnancy induced hypertensive disorders in South Australia - A retrospective population study 2007-2011.

Pregnancy Hypertens. 2015 Jan;5(1):91. doi: 10.1016/j.preghy.2014.10.183
Verburg PE1, Tucker G2, Scheil W2, Erwich JJ1, Roberts CT3, Dekker GA3.

VitaminDWiki Summary

4 years, 4252 pregnancies,
7% had pregnancy induced hypertensive disorders (PIHD, which leads to preeclampsia)

To assess the seasonal variation of pregnancy induced hypertensive disorders (PIHD) in an Australian population.

Retrospective study of 59,993 South Australian singleton live born births, for whom a body mass index (BMI) of the mother and sex of the baby were recorded, during 2007-2011 in the South Australian Perinatal Statistics Collection. The incidence of PIHD in relation to birth date was assessed. Fourier series analysis was used to model seasonal trends.

Of a total of 59,993 births recorded during the study period 4252 (7.1%) women were diagnosed with PIHD. Seasonal modelling showed a strong relation between PIHD and date of birth (p<0.000). When adjusted for confounders (age, BMI, race, smoking during second half of pregnancy, parity and gestational diabetes) the model still showed a strong relation between PIHD and date of birth (p<0.000). The peak prevalence occurred among births in Winter (Jun/Jul/Aug), with a trough in pregnancies with birth in (late-) Summer (Jan/Feb).

These epidemiological data support seasonal periodicity for PIHD in an Australian population. The highest incidence of PIHD was associated with birth in the Winter months (Jun/Jul/Aug). The etiology of PIHD is still elusive, but theories include

  • genetic and immune mechanisms,
  • (abnormal placentation
  • cardiovascular maladaptation to pregnancy,
  • nutritional, hormonal and angiogenetic factors and
  • enhanced systemic inflammatory response.

Recent studies found a relation between both infection and low maternal vitamin D levels and pre-eclamspia. These conditions could explain the detected seasonality for PIHD. Further investigation into the biological mechanism(s) for this finding should be undertaken to identify additional risk factors, so PIHD can be prevented in the clinic.

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See also VitaminDWiki

Preeclampsia (hypertension while pregnant) varies with season (O.R. 0.57) – June 2021

Pregnancy category starts with

864 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Attached files

ID Name Comment Uploaded Size Downloads
15783 preg hypertension 2015.pdf admin 22 Jun, 2021 18:12 178.18 Kb 235
5198 Preeclampsia winter.jpg admin 20 Mar, 2015 14:04 41.61 Kb 1509