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Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014


  • Pre-eclampsia or preeclampsia (PE) is a disorder of pregnancy characterized by high blood pressure and a large amount of protein in the urine
  • Preeclampsia affects 2–8% of pregnancies worldwide
  • Those with long term high blood pressure have a risk 7 to 8 times higher than those without.
  • The incidence of pre-eclampsia has risen in the USA since the 1990s

Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis

Ann Nutr Metab 2013;63:331-340 , link Free Supplementary Material, (DOI:10.1159/000358338)
Hyppönen E. a-c · Cavadino A.c · Williams D.d · Fraser A.e · Vereczkey A.g · Fraser W.D.f · Bánhidy F.h · Lawlor D.e · Czeizel A.E.i
A School of Population Health and Sansom Institute, University of South Australia, and b South Australian Health and Medical Research Institute, Adelaide, S.A., Australia; cCentre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, and d Institute for Women's Health, University College Hospital, London, e MRC CAiTE Centre, School of Social and Community Medicine, University of Bristol, Bristol, and f Norwich Medical School, University of East Anglia, Norwich, UK; g Versys Clinics, Human Reproduction Institute, h Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, and I Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Prof. Elina Hyppönen; School of Population Health; University of South Australia, GPO Box 2471; North Terrace, Adelaide, SA 5001 (Australia); elina.hypponen at unisa.edu.au

Background/Aims: Vitamin D may protect from pre-eclampsia through influences on immune modulation and vascular function. To evaluate the role of vitamin D in the development of pre-eclampsia, we conducted a systematic review and meta-analysis including novel data from 2 large-scale epidemiological studies.

Methods: PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched for prospective observational studies of association between vitamin D supplementation or status (measured by maternal 25-hydroxyvitamin D, 25(OH)D) with a subsequent risk of pre-eclampsia, or randomised controlled trials using vitamin D supplementation to prevent pre-eclampsia. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) and the Avon Longitudinal Study of Parents and Children (ALSPAC) were included in meta-analyses with published studies.

Results: Mothers receiving vitamin D supplementation earlier in pregnancy had lower odds of pre-eclampsia [pooled odds ratios (OR) 0.81 and 95% confidence interval (CI) 0.75-0.87, p = 2.4 × 10-8, 2 studies] in the meta-analysis of published studies with HCCSCA. The meta-analysis of published studies with ALSPAC suggested an association between higher serum 25(OH)D levels and a reduced risk of pre-eclampsia (pooled __OR 0.52_ and 95% CI 0.30-0.89, p = 0.02, 6 studies). Randomised trials of supplementation were suggestive of protective association (pooled OR 0.66 and 95% CI 0.52-0.83, p = 0.001, 4 studies).

Conclusions: This study suggests that low maternal serum 25(OH)D concentrations increase pre-eclampsia risk and that vitamin D supplementation lowers this risk. The quality of evidence is insufficient to determine a causal association, which highlights the need for adequately powered clinical trials.

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See also VitaminDWiki

The articles in Pregnancy AND Hypertension (proxy) are here:

See also Vitamin D Council on preeclampsia excellent summary April 2013

NY Times reporting on low-dose aspirin reducing preeclampsia by 25% April 2014

The Association between Maternal Vitamin D Status in Gestation and Pre-Eclampsia - 2014

 Download the PDF from VitaminDWiki.

Attached files

ID Name Comment Uploaded Size Downloads
4613 preeclampsia Arsala 2014.pdf admin 22 Nov, 2014 842.47 Kb 1260
3678 pre-eclampsia T2.jpg admin 06 Mar, 2014 25.37 Kb 5871
3677 pre-eclampsia meta.jpg admin 06 Mar, 2014 23.56 Kb 1820
3676 pre-eclampsia_Suppl._Material.zip admin 06 Mar, 2014 254.33 Kb 780
3675 pre-elampsia meta-analysis.pdf admin 06 Mar, 2014 172.79 Kb 1484