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Risk of preeclampsia should drop to nearly zero at 60 ng of Vitamin D – July 2022

The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study

Nutrients 2022, 14(15), 3008; https://doi.org/10.3390/nu14153008
by George Dahma 1,Radu Neamtu 1ORCID,Razvan Nitu 1,*,Adrian Gluhovschi 1ORCID,Felix Bratosin 2ORCID,Mirela Loredana Grigoras 2,Carmen Silaghi 1,Cosmin Citu 1ORCID,Igwe Nwobueze Orlu 3,Sanket Bhattarai 4ORCID,Adelina Geanina Mocanu 1,Marius Craina 1 andElena Bernad 1ORCID

  • 1 Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
  • 2 Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
  • 3 Faculty of General Medicine, University of Debrecen Medical School, Nagyerdei Street 94, 4032 Debrecen, Hungary
  • 4 KIST Medical College, Imadol Marg, Lalitpur 44700, Nepal


Preeclampsia is a pregnancy-specific illness that is hypothesized to occur due to vitamin D deficiency during pregnancy. Therefore, vitamin D supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal well-being. The present study follows a case-control analysis that aims to determine the effect of vitamin D supplements on reducing the probability of recurrent preeclampsia. We identified 59 patients for the control group without vitamin D supplementation during pregnancy, while 139 patients were included in the cases group of pregnant women with a history of preeclampsia who confirmed taking daily vitamin D supplements in either 2000 UI or 4000 UI until the 36th week of pregnancy. There were 61 (80.3%) patients with a normal serum vitamin D level measured at 32 weeks in the pregnant women who took a daily dose of 4000 UI vitamin D and 43 (68.3%) in those who took a 2000 UI dose of vitamin D, compared to just 32 (54.2%) in those who did not take vitamin D at all. Regarding the blood pressure of pregnant women measured at 32 weeks, it was observed that 20.3% were hypertensive in the no supplementation group, compared to only 11.1% and 6.6% in those who were taking vitamin D during pregnancy (p-value = 0.049). Serum vitamin D levels at 32 weeks were measured at an average value of 23.9 ng/mL, compared with 28.4 ng/mL in the group taking a 2000 UI daily dose and 33.6 in those who supplemented with 4000 UI daily (p-value < 0.001).

Proteinuria was identified more often in the group at risk for preeclampsia who did not take vitamin D supplements, while systolic blood pressure (p-value = 0.036) as well as diastolic blood pressure (p-value = 0.012), were all identified to have significantly higher values in the pregnant women with a history of preeclampsia that did not take vitamin D during the current pregnancy.

The significant risk factors for preeclampsia development in pregnant patients at risk are: insufficient vitamin D serum levels (<20 ng/mL), OR = 2.52; no vitamin D supplementation, OR = 1.46; more than two pregnancies, OR = 1.89; gestational diabetes mellitus, OR = 1.66; and cardiovascular comorbidities, OR = 2.18. These findings imply that vitamin D has a role in the preservation of placental function and, therefore, in the prevention of the development of late preeclampsia. Pregnant mothers who supplemented their diets with vitamin D were protected against preeclampsia recurrence. Vitamin D supplementation during pregnancy may aid in the prevention of gestational hypertension and preeclampsia.
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VitaminDWiki - 44 studies in both categories Pregnancy and Hypertension

This list is automatically updated

40-150 ng of Vitamin D need to treat various health problems

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
ACL recovery
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors

Created by admin. Last Modification: Friday July 22, 2022 15:54:59 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
18162 Preeclampsia 0, 2000, 4000.jpg admin 22 Jul, 2022 21.29 Kb 201
18161 Risk of preeclampsia.jpg admin 22 Jul, 2022 41.25 Kb 378
18160 Preeclampsia July 2022_CompressPdf.pdf admin 22 Jul, 2022 267.91 Kb 69