Preclinical serum 25-hydroxyvitamin D levels and risk of type 1 diabetes in a cohort of US military personnel.
Am J Epidemiol. 2013 Mar 1;177(5):411-9. doi: 10.1093/aje/kws243. Epub 2013 Feb 3.
Munger KL, Levin LI, Massa J, Horst R, Orban T, Ascherio A.
Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA. kgorham at hsph.harvard.edu
To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) in young adults are associated with risk of type 1 diabetes mellitus (T1D), we conducted a prospective, nested case-control study among US active-duty military personnel with serum in the US Department of Defense Serum Repository, identifying 310 T1D cases diagnosed between 1997 and 2009 with at least 2 serum samples collected before disease onset and 613 controls matched to cases on age, sex, race/ethnicity, branch of military service, and dates of serum collection. Conditional logistic regression was used to estimate rate ratios and 95% confidence intervals.
Among non-Hispanic whites, those with average 25(OH)D levels of ≥ 100 nmol/L had a 44% lower risk of developing T1D than those with average 25(OH)D levels < 75 nmol/L (rate ratio = 0.56, 95% confidence interval: 0.35, 0.90, P for trend = 0.03) over an average follow-up of 5.4 years. In quintile analyses, T1D risk was highest among individuals whose 25(OH)D levels were in the lowest 20% of those measured.
There was no association between 25(OH)D levels and risk of T1D among non-Hispanic blacks or Hispanics. Low 25(OH)D levels may predispose healthy, young, non-Hispanic white adults to the development of T1D.
- Overview Diabetes and vitamin D
- Type 1 diabetes strongly associated with low vitamin D – March 2013
- Type 1 Diabetes probability reduced by 2X if have more than 40 ng of vitamin D – Feb 2013
- Type 1 Diabetes associated with low vitamin D, especially in dark skinned youths – Dec 2012 yet the study on this page found no relationship
- Prevent half of T1 Diabetes with vitamin D levels of 50 ng – Dec 2012
- Probability of Type I diabetes reduced 29 percent with vitamin D – systematic review July 2012