Health effects in vaccinated versus unvaccinated children, with covariates for breastfeeding status and type of birth - June 2021
Journal of Translational Science June 2021 DOI: 10.15761/JTS.1000459
Brian S. Hooker: Department of Sciences and Mathematics, Simpson University, Redding, California 96003 USA
Neil Z. Miller" Institute of Medical and Scientific Inquiry, Santa Fe, New Mexico 87506 USA
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Using survey data from respondents associated with three medical practices in the US, vaccinated children were compared to unvaccinated children for the incidence of severe allergies, autism, gastrointestinal disorders, asthma, ADHD, and chronic ear infections. All diagnoses were based on parental reporting with chart review for confirmation of diagnoses. Cases were stratified with non-cases based on year of birth and sex, and compared using a logistic regression model which also accounted for breastfeeding status and type of birth (vaginal versus cesarean section).
Vaccinated children were significantly more likely than unvaccinated children to be diagnosed with
- severe allergies (OR = 4.31, 95% CI 1.67 - 11.1),
- autism (OR = 5.03, 95% CI 1.64 - 15.5),
- gastrointestinal disorders (OR = 13.8, 95% CI 5.85 - 32.5),
- asthma (OR = 17.6, 95% CI 6.94 - 44.4),
- ADHD (OR = 20.8, 95% CI 4.74 - 91.2), and
- chronic ear infections (OR = 27.8, 95% CI 9.56 - 80.8).
Vaccinated children were less likely to be diagnosed with chickenpox (OR = 0.10, 95% CI 0.029 - 0.36).
Children who were "vaccinated and not breastfed" or "vaccinated and delivered via cesarean section" had the highest rates of adverse health outcomes.
In this study, higher ORs were observed within the vaccinated versus unvaccinated groups for several adverse health conditions. Further research is essential to understand the full scope of health effects associated with childhood vaccination.
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