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Myocarditis, Pericarditis 2X more likely if had COVID vaccination in previous 30 days - meta-analysis June 2023


Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis

BMJ Open 2023;13:e065687. doi: 10.1136/bmjopen-2022-065687
Abdallah Alami1, Daniel Krewski2,3, Nawal Farhat1, Donald Mattison2,3,4, Kumanan Wilson5,6, Christopher A Gravel2,7,8, Patrick J Farrell1, James A G Crispo9,10, Nisrine Haddad2, Santiago Perez-Lloret11,12,13, Paul J Villeneuve14 Correspondence to Abdallah Alami; abdallahalami at cmail.carleton.ca

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Objective To summarise the available evidence on the risk of myocarditis and/or pericarditis following mRNA COVID-19 vaccination, compared with the risk among unvaccinated individuals in the absence of COVID-19 infection.

Design Systematic review and meta-analysis.

Data sources Electronic databases (Medline, Embase, Web of Science and WHO Global Literature on Coronavirus Disease), preprint repositories (medRxiv and bioRxiv), reference lists and grey literature were searched from 1 December 2020 until 31 October 2022.

Study selection Epidemiological studies of individuals of any age who received at least one dose of an mRNA COVID-19 vaccine, reported a risk of myo/pericarditis and compared the risk of myo/pericarditis to individuals who did not receive any dose of an mRNA COVID-19 vaccine.

Data extraction and synthesis Two reviewers independently conducted screening and data extraction. The rate of myo/pericarditis among vaccinated and unvaccinated groups was recorded, and the rate ratios were calculated. Additionally, the total number of individuals, case ascertainment criteria, percentage of males and history of SARS-CoV-2 infection were extracted for each study. Meta-analysis was done using a random-effects model.

Results Seven studies met the inclusion criteria, of which six were included in the quantitative synthesis. Our meta-analysis indicates that within 30-day follow-up period, vaccinated individuals were twice as likely to develop myo/pericarditis in the absence of SARS-CoV-2 infection compared to unvaccinated individuals, with a rate ratio of 2.05 (95% CI 1.49–2.82).

Conclusion Although the absolute number of observed myo/pericarditis cases remains quite low, a higher risk was detected in those who received mRNA COVID-19 vaccinations compared with unvaccinated individuals in the absence of SARS-CoV-2 infection. Given the effectiveness of mRNA COVID-19 vaccines in preventing severe illnesses, hospitalisations and deaths, future research should focus on accurately determining the rates of myo/pericarditis linked to mRNA COVID-19 vaccines, understanding the biological mechanisms behind these rare cardiac events and identifying those most at risk.
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VitaminDWiki - 19 studies in both categories Virus and Cardiovascular

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Attached files

ID Name Comment Uploaded Size Downloads
20011 Myo table.jpg admin 25 Aug, 2023 63.27 Kb 117
20010 Myo RR.jpg admin 25 Aug, 2023 47.00 Kb 110
20008 Risk of myocarditis and pericarditis_CompressPdf.pdf admin 25 Aug, 2023 545.04 Kb 106