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Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024


Vitamin D efficacy in type 1 and type 2 diabetes

Journal of Bone and Mineral Metabolism  April 2024 https://doi.org/10.1007/s00774-024-01509-3
Tetsuya Kawahara, Yosuke Okada & Yoshiya Tanaka

It is well known that vitamin D has a profound effect on calcium and bone metabolism, but its influence on other organs (extraskeletal effect) has been proposed. Consistently, vitamin D deficiency is associated with an increased incidence of various diseases, including type 1 and type 2 diabetes, as reported by many observational studies. However, there has been no consensus on whether vitamin D deficiency is a causative factor in the incidence of diabetes mellitus. There have been no randomized controlled trials (RCTs) aimed at preventing the onset of type 1 diabetes with vitamin D intake. In addition, the results of RCTs evaluating the preventive effect of vitamin D supplementation on type 2 diabetes development have been inconsistent. The recent observational studies, randomized controlled trials, and meta-analyses are confirming that vitamin D or active vitamin D administration is effective in preventing the incident of type 1 and type 2 diabetes.

Conclusion

Observational studies have shown that vitamin D/cod liver oil intake in the infancy period may be effective in prevent­ing the onset of type 1 diabetes. In addition, vitamin D used as adjunctive therapy with insulin may be associated with a protective immunologic effect and slow decline of residual beta cell function in patients with new-onset type 1 diabetes.
RCTs and meta-analyses showed that vitamin D/active vitamin D administration is slightly effective in prevent­ing type 2 diabetes development. Based on these results, the American Diabetes Association guidelines 2024 have adopted a policy of “recommending vitamin D and active vitamin D administration for patients with prediabetes to prevent type 2 diabetes development’'. The results of RCT in prediabetes adults with reduced basal insulin secre­tion, which may provide additional vitamin D benefits, are warranted.
However, prescribing of vitamin D/active vitamin D with delusive belief should be avoided. After prescribing them, we must follow up patients with attention to the appearance of side effects.

Note: Perplexity AI was NOT able to find an ADA reference


VitaminDWiki – Overview Diabetes and vitamin D contains

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 548 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:

  • Dark Skin 24;   Intervention 56;   Meta-analysis 39;   Obesity 36;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 13;  Magnesium 29    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes

Pre-Diabetes

Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image

34+ VitaminDWiki pages with PREDIABETES or PREDIABETIC in title

This list is automatically updated

Items found: 34
Title Modified
Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024 28 Apr, 2024
4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023 01 May, 2023
Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022 22 Dec, 2022
Depression more likely if low vitamin D (3.5 X prediabetic women in this case) – Oct 2022 25 Oct, 2022
Prediabetes in US youths increased 2X in 2 decades - March 2022 03 Apr, 2022
Vitamin D given for 6 weeks did not slow prediabetes progression 2 years later (no surprise) – RCT Aug 2021 27 Aug, 2021
Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020 06 Apr, 2021
Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021 23 Feb, 2021
US young adults – 24 percent have prediabetes (many low-cost ways to treat)– Jan 2020 10 Jan, 2020
Prediabetics had different gut bacteria – April 2018 30 Dec, 2019
Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019 10 Oct, 2019
Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019 29 Jul, 2019
Prediabetes both prevented and treated by monthly Vitamin D, etc. 08 Jun, 2019
Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018 24 Feb, 2019
Prediabetics not helped by weekly vitamin D (perhaps D2) – RCT Oct 2013 09 Dec, 2018
Prediabetics not benefit from vitamin D, perhaps D2 was used – RCT Feb 2013 09 Dec, 2018
Prediabetes starts to be treated by 3,800 IU of Vitamin D – meta-analysis July 2018 28 Aug, 2018
Zinc cut in half the rate of prediabetes progressing to diabetes (20 mg) – RCT Oct 2017 28 Feb, 2018
Zinc cut in half the rate of prediabetes progressing to diabetes (20 mg) – RCT Oct 2018 28 Feb, 2018
Prediabetes corrected in 3 months by 1,000 IU of vitamin D as pill or in yogurt – RCT Jan 2018 29 Jan, 2018
Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015 15 Mar, 2017
Normalizing vitamin D levels reduced prediabetic measure by 18 percent – RCT Oct 2012 15 Mar, 2017
Fewer mice became prediabetic when given Vitamin D, even when on high fat, high sugar diet – March 2017 15 Mar, 2017
Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016 11 Mar, 2017
Prediabetes reduced in half by those getting Magnesium Chloride – RCT April 2015 28 Jan, 2017
Prediabetics not helped by 50,000 IU of vitamin D weekly and Calcium– Jan 2013 03 Apr, 2016
Prediabetes reduced after restoring Magnesium levels – RCT April 2015 02 Aug, 2015
Prediabetes progression to diabetes 25 percent less for every 4 ng increase in vitamin D – April 2012 03 May, 2015
Prediabetic have very different gut bacteria – March 2015 09 Mar, 2015
1 in 10 Chinese adults are diabetics and 15 percent prediabetic - Mar 2010 06 Mar, 2015
Prediabetics 60 percent less likely to become diabetic if given some vitamin D – Jan 2014 25 Jan, 2014
27 percent less likely to develop diabetes if prediabetic and have adequate vitamin D – Mar 2012 25 Jan, 2014
12700 IU daily vitamin D3 did not stop prediabetic minorities from becoming diabetic – June 2012 10 Jun, 2012
You Can Reverse PreDiabetes – Nov 2009 04 Jul, 2010