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- Integrated bioinformatics and in silico approaches reveal the biological targets and molecular mechanisms of 1,25-dihydroxyvitamin D against COVID-19 and diabetes mellitus
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10 studies in both categories Virus and Diabetes
Integrated bioinformatics and in silico approaches reveal the biological targets and molecular mechanisms of 1,25-dihydroxyvitamin D against COVID-19 and diabetes mellitus
Front Nutr. 2022 Dec 2;9:1060095. doi: 10.3389/fnut.2022.106009
Fanqiang Zeng 1, Yongli Xu 2, Chaoling Tang 3, Zhigang Yan 2, Chaohe Wei 1Coronavirus disease 2019 (COVID-19) and diabetes mellitus (DM) are two major diseases threatening human health. The susceptibility of DM patients to COVID-19 and their worse outcomes have forced us to explore efficient routes to combat COVID-19/DM. As the most active form of Vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) has been shown a beneficial effect in the treatment of COVID-19/DM. However, the anti-COVID-19/DM mechanisms of 1,25(OH)2D remain unclear. In this study, an approach combining network pharmacology and molecular docking was performed to reveal the potential hub target genes and underlying mechanisms of 1,25(OH)2D in the treatment of COVID-19/DM. The hub targets and interaction pathways related to 1,25(OH)2D were identified by integrating the key 1,25(OH)2D-target-signaling pathway-COVID-19/DM networks.
Fifteen hub targets of 1,25(OH)2D against COVID-19DM were determined, including EGFR, PIK3R1, PIK3CA, STAT3, MAPK1, ESR1, HSP90AA1, LCK, MTOR, IGF1, AR, NFKB1, PIK3CB, PTPN1, and MAPK14. An enrichment analysis of the hub targets further revealed that the effect of 1,25(OH)2D against COVID-19/DM involved multiple biological processes, cellular components, molecular functions and biological signaling pathways. Molecular docking disclosed that 1,25(OH)2D docked nicely with the hub target proteins, including EGFR, PIK3R1, and PIK3CA. These findings suggested that the potential mechanisms of 1,25(OH)2D against COVID-19/DM may be related to multiple biological targets and biological signaling pathways.
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10 studies in both categories Virus and Diabetes This list is automatically updated
- Active vitamin D is related to COVID and Diabetes in 15 ways – Dec 2022
- T1 Diabetic adults 5X more likely to get COVID (hint low vitamin D)– Nov 2022
- Vitamin D separately helps X or COVID, should help X with COVID (example: diabetes) – March 2022
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- Diabetes has many bidirectional links with COVID-19 – March 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Hyperglycemic 2X more likely to have severe COVID-19 - Nov 2020
- Diabetes increases COVID-19 severity and COVID-19 creates Diabetes - Oct 2020
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
Active vitamin D is related to COVID and Diabetes in 15 ways – Dec 2022Printer Friendly Follow this page for updates166 visitors, last modified 20 Dec, 2022, This page is in the following categories (# of items in each category)