Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry
Annals of Medicine, Volume 53, 2021 - Issue 1. DOI: 10.1080/07853890.2020.1836566
Francisco Javier Carrasco-Sánchez ORCID Icon,Mª Dolores López-Carmona,Francisco Javier Martínez-Marcos,Luis M. Pérez-Belmonte,Alicia Hidalgo-Jiménez,Verónica Buonaiuto
This study looked at 11,000 COVID-19 patients in the Spring
- Hyperglycemia associated with low vitamin D – type II diabetics and healthy people – meta-analysis Jan 2018
- How Vitamin D prevents Hyperglycemia – Sept 2020
Items in both categories Virus and Diabetes are listed here:
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Diabetes 3X more likely if had COVID ICU (VDR was de-activated) - April 2023
- Active vitamin D is related to COVID and Diabetes in 15 ways – Dec 2022
- T1 Diabetic adults 5X more likely to get COVID (hint low vitamin D)– Nov 2022
- Vitamin D separately helps X or COVID, should help X with COVID (example: diabetes) – March 2022
- COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021
- Diabetes has many bidirectional links with COVID-19 – March 2021
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Hyperglycemic 2X more likely to have severe COVID-19 - Nov 2020
- Diabetes increases COVID-19 severity and COVID-19 creates Diabetes - Oct 2020
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
This study was reported by:
Blood glucose on admission predicts COVID-19 severity in all MDEdge Nov 30
Outcomes vs level
All-cause COVID-19 mortality
Table 4. Association with composite outcome (death, mechanical ventilation and/or ICU admission).
OR: odds ratio; COPD: chronic obstructive pulmonary disease; CRP: C-reactive protein; LDH: lactate dehydrogenase. Adjusted multivariate logistic regression model. The model included all variables of medical history and laboratory findings
Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19.
This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140–180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality.
Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140–180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31–1.73) (BG 140–180 mg/dL; HR 1.48; 95%CI: 1.29–1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality.
Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes.
- Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19.
- Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19.
- Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.
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