Toggle Health Problems and D

Type 1 diabetes strongly associated with low vitamin D – March 2013

The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus.

Int J Endocrinol. 2013;2013:148673. doi: 10.1155/2013/148673. Epub 2013 Mar 13.
Chakhtoura M, Azar ST.
Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York, NY 10017, USA.

The "nonclassic" role of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been recently widely recognized. In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role through the vitamin D receptor (VDR) present on pancreatic and immune cells. Specific VDR allelic variants have been associated with T1D in many countries. Furthermore, vitamin D deficiency has been prevalent in T1D, and the seasonal and latitude variability in the incidence of T1D can be partly explained by the related variability in vitamin D level. In fact, retrospective studies of vitamin D supplementation during pregnancy or infancy showed a lower incidence of T1D. We will review the different mechanisms of the vitamin D protective effect against insulitis and present the available data on the role of vitamin D deficiency in the control, progression, and complications of T1D.

PMID: 23573085

PDF is attached at the bottom of this page

See also VitaminDWiki

See also web

Attached files

ID Name Comment Uploaded Size Downloads
2335 T1 diabetes.pdf admin 12 Apr, 2013 630.82 Kb 1297