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Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 6 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (23 studies), Hypertension (7 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (23 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (32 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

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Items found: 411
Title Modified
Prostate cancer outcomes vary with Vitamin D Receptors– May 2017 16 Jun, 2017
Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015 15 Jun, 2017
Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017 15 Jun, 2017
The vitamin D receptor and T cell function – June 2013 11 May, 2017
Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017 23 Apr, 2017
Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017 20 Apr, 2017
Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013 20 Apr, 2017
Vitamin D - Binding Protein, Receptor, enzymes and health benefits - review Jan 2016 15 Apr, 2017
Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016 20 Mar, 2017
Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015 17 Mar, 2017
Herpes (Cytomegalovirus) downregulates the vitamin D receptor by 8X – Jan 2017 17 Mar, 2017
The vitamin D receptor (publisher wants 10 dollars for this update) – Feb 2017 17 Mar, 2017
Vitamin D Receptor problems occur 5 times for often with Nasal polyposis – Nov 2016 12 Mar, 2017
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 06 Mar, 2017
Hair loss strongly associated with poor vitamin D receptors– Dec 2016 05 Mar, 2017
Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015 05 Mar, 2017
2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017 04 Mar, 2017
Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017 02 Mar, 2017
Low back pain in athletes 6 times more likely if poor Vitamin D Receptor – Feb 2017 02 Mar, 2017
Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 02 Mar, 2017
Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017 01 Mar, 2017
Helicobacter pylori infection protection by the body’s increasing Vitamin D receptors – Nov 2013 27 Feb, 2017
Vitamin D and receptor reduce carcinogenic effects of pollutants – July 2015 27 Feb, 2017
Vitamin D receptor substitutes are being patented – Sept 2015 27 Feb, 2017
Vitamin D Receptor gene relationship to lower back pain – study funded June 2013 27 Feb, 2017
Vitamin D receptor may suppress skin cancer – Dec 2013 27 Jan, 2017
Myopia 2 times more likely if Vitamin D Receptor problem – June 2011 12 Jan, 2017
Vitamin D receptor has 1496 variants – Dec 2016 10 Jan, 2017
Vitamin D Receptor report costs 1250 dollars – May 2015 24 Dec, 2016
Vitamin D Receptor and Obesity – several studies 17 Dec, 2016
Vitamin D Receptor test for 29 dollars (there are 5 more Vitamin D genes) – Oct 2016 15 Dec, 2016
Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016 10 Dec, 2016
Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016 06 Dec, 2016
Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012 05 Dec, 2016
Vitamin D, Vitamin D Receptor and Cancer – Nov 2016 05 Dec, 2016
Rheumatoid arthritis is 40 percent more likely in Caucasians with a vitamin D receptor problem – meta-analysis Sept 2015 05 Dec, 2016
Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017 25 Nov, 2016
Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016 24 Nov, 2016
High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016 14 Nov, 2016
Calcium and vitamin D receptors are important to many health conditions – Jan 2013 14 Nov, 2016
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 14 Nov, 2016
Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016 12 Nov, 2016
Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016 12 Nov, 2016
Parkinson's disease cognitive decline associated with poor Vitamin D receptor – Nov 2016 12 Nov, 2016
Muscle strength is associated with vitamin D receptor gene variants – March 2016 12 Nov, 2016
Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013 12 Nov, 2016
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 12 Nov, 2016
Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014 12 Nov, 2016
Spinal disc degeneration is associated with vitamin D receptor genes, and others – March 2013 31 Oct, 2016
2,776 vitamin D receptor binding sites - April 2014 29 Oct, 2016
Vitamin D (and VDR) – Vieth book chapter - 2017 26 Oct, 2016
Surprise:Three different types of vitamin D can activate the vitamin D receptor – Oct 2013 26 Oct, 2016
Vitamin D Receptor locations – Dec 2012 26 Oct, 2016
2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014 26 Oct, 2016
Preterm birth 3.3 times more likely if Vitamin D Receptor gene problem – Aug 2016 15 Oct, 2016
Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016 29 Sep, 2016
Dental carries associated with poor vitamin D receptor (TaqI genotypes) – 2016 26 Sep, 2016
Hip fracture risk increased 2.5X if problem with Vitamin D Receptor gene (GC) – March 2014 25 Sep, 2016
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 23 Sep, 2016
Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014 23 Sep, 2016
Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016 22 Jul, 2016
Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analysis March 2013 22 Jul, 2016
Dengue Fever associated with poor vitamin D receptor – July 2002 01 May, 2016
Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016 24 Mar, 2016
Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 17 Mar, 2016
Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 06 Jan, 2016
COPD strongly associated with Vitamin D receptor problems – meta-analysis Aug 2015 01 Dec, 2015
Growth Hormone problem (Acromegaly) 50 percent more likely if vitamin D receptor problem – March 2015 07 Nov, 2015
Vitamin D Receptors can be activated by other than Vitamin D - March 2015 18 Oct, 2015
Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 18 Oct, 2015
Resistance exercise increases Vitamin D receptor for a few hours (in rats) – Oct 2015 17 Oct, 2015
Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015 13 Oct, 2015
Vitamin D Receptor can be modulated with a new compound – Feb 2014 01 Oct, 2015
Different response by Vitamin D Receptor to Vitamin D vs Vit. D analogs – Sept 2015 24 Sep, 2015
Vitamin D Receptor and immune differences between mice and men – Sept 2015 16 Sep, 2015
Vitamin D receptor genes vary a lot between races – Dec 2015 16 Sep, 2015
Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012 10 Sep, 2015
2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015 09 Sep, 2015
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Vitamin D receptor functionality improved with probiotics – Sept 2015 02 Sep, 2015
Hypothesis Vitamin D receptor controls PTH without needing Vitamin D – Aug 2015 01 Sep, 2015
Poorly functioning Vitamin D Receptor (VDR) was 5X more likely in children with low vitamin D levels – July 2012 09 Aug, 2015
Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014 04 Aug, 2015
Vitamin D Receptors are important for health (technical)– May 2015 04 Aug, 2015
Genes in the blood are not static, 20 percent change with the seasons - such as Vitamin D Receptor – May 2015 13 May, 2015
Leprosy associated with changes to Vitamin D receptor genes (VDR)– April 2015 19 Apr, 2015
Health outcomes of vitamin D. Parts I (VDR) and II – 2014 23 Jan, 2015
Diseases, Vitamin D Receptor and other genes – June 2014 13 Jan, 2015
Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014 29 Dec, 2014
Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014 17 Dec, 2014
Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 26 Nov, 2014
Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014 13 Jul, 2014
Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014 28 May, 2014
T1DM, toll-like receptors and vitamin D in rats – May 2014 21 May, 2014
Vitamin D receptor activation and Chronic Kidney Disease – Oct 2011 14 May, 2014
Subsequent melanomas associated with BsmI gene variation of VDR– May 2011 22 Mar, 2014
Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014 19 Mar, 2014
Vitamin D Receptor technical details – Jan 2010 11 Jan, 2014
The Overlooked Importance of VITAMIN D RECEPTORS - LEF Aug 2013 08 Jan, 2014
Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013 06 Jan, 2014
Created by admin. Last Modification: Monday October 3, 2022 16:22:58 GMT-0000 by admin. (Version 7)
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022        
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