Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 5 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (22 studies), Cognition (16 studies), Diabetes (22 studies), Hypertension (7 studies), Infant (18 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (30 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

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Items found: 404
Title Modified
Non-Hodgkin’s lymphoma associated with poor Vitamin D receptor – Feb 2021 27 Jan, 2023
Natural activators of the Vitamin D Receptor - some immune cells - April 2023 20 Jan, 2023
Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 08 Jan, 2023
Vitamin D Receptor 01 Jan, 2023
COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) -several studies 01 Jan, 2023
Less radiation-induced intestinal injury if activate the Vitamin D receptor (mice) – Dec 2022 29 Dec, 2022
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 06 Dec, 2022
Gastric Cancer, Vitamin D, VDR, UV - many studies 10 Nov, 2022
Lupus associated with another poor vitamin D gene (CYP27B1 – in addition to low Vitamin D and poor VDR) – Aug 2022 04 Nov, 2022
Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022 31 Oct, 2022
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022 03 Oct, 2022
COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022 29 Sep, 2022
A healthy gut needs Vitamin D and a good vitamin D receptor – Sept 2022 20 Sep, 2022
Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case) Sept 2022 06 Sep, 2022
Alzheimer's disease 9X more likely in females with a poor Vitamin D Receptor – Sept 2022 27 Aug, 2022
Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022 24 Aug, 2022
Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022 15 Aug, 2022
Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022 11 Aug, 2022
Vitamin D Receptors are both inside the cell and at the cell membrane – July 2020 09 Aug, 2022
CBD may be synergistic with Vitamin D (improves VDR in rats) - Aug 2022 08 Aug, 2022
Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022 04 Aug, 2022
PFAS (forever chemicals) reduce Vitamin D and VDR, cause health problems - many studies 29 Jul, 2022
Some breast cancers may prevented by VDR – March 2022 27 Jul, 2022
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 27 Jul, 2022
COVID 3X more likely if a poor Receptor (cells get less Vitamin D from the blood) – July 2022 21 Jul, 2022
2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022 04 Jul, 2022
14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement) 01 Jul, 2022
Poor oral bacteria associated with poor Vitamin D Receptor - June 2022 24 Jun, 2022
Parkinson’s Disease 3 X more likely if a poor Vitamin D Receptor – May – 2022 06 May, 2022
Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022 23 Apr, 2022
Alzheimer's disease 1.8 X higher risk if poor Vitamin D Receptor (if not take action) - May 2022 11 Apr, 2022
Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022 07 Apr, 2022
BPH increased risk if poor Vitamin D Receptor in Asians – meta-analysis April 2022 06 Apr, 2022
Vitamin D up and down regulates 1,000’s of genes via the Vitamin D Receptor – March 2022 24 Mar, 2022
Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022 14 Mar, 2022
Parkinson's Disease associations with Vitamin D Receptor and GC gene – June 2016 14 Mar, 2022
Poor Vitamin D receptor reduced vitamin D levels -meta-analysis Jan 2022 23 Jan, 2022
The Vitamin D Receptor is associated with many health problems 26 Dec, 2021
Intense exercise increases vitamin D receptor activation 26 Dec, 2021
COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021 25 Dec, 2021
Different Vitamin D Receptor problems cause different COVID problems - Dec 2021 18 Dec, 2021
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
COVID, influenza, hepatitis B, measles, etc. vaccine responses vary with Vitamin D and its receptor 08 Dec, 2021
Gout 1.5 X more likely if a poor Vitamin D Receptor – 2014 04 Nov, 2021
Cancers and Vitamin D Receptors, including change with race – Feb 2021 24 Oct, 2021
Needing a high level of vitamin D is a good clue that the Vitamin D Receptor is deactivated 18 Oct, 2021
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies 18 Oct, 2021
Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021 17 Oct, 2021
Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010 17 Oct, 2021
COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021 09 Oct, 2021
Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020 09 Oct, 2021
Little Vitamin D benefit if poor Vitamin D Receptor (400 studies annually) - Oct 2021 05 Oct, 2021
Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018 02 Oct, 2021
PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021 23 Sep, 2021
Skin scars (Keloids) more likely if low vitamin D, poor Vitamin D receptor, or dark skin – Aug 2021 13 Sep, 2021
Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021 16 Aug, 2021
The vitamin d receptor and T cell function- June 2013 05 Aug, 2021
Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 04 Aug, 2021
Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021 08 Jul, 2021
Male Infertility is associated with poor Vitamin D Receptor – July 2021 04 Jul, 2021
Poor male fertility is association with poor Vitamin D Receptor (less D to the cells) – July 2021 02 Jul, 2021
Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019 01 Jul, 2021
2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021 25 Jun, 2021
Graves' disease 2X more likely if poor Vitamin D Receptor (like many other autoimmune diseases) – May 2021 03 Jun, 2021
Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies 24 May, 2021
Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020 23 May, 2021
Cytomegalovirus downregulates Vitamin D receptor, but tissues respond by increasing production – Sept 2016 19 May, 2021
Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021 26 Apr, 2021
Jaw joint (TMJ) needs 30-50 ng of Vitamin D and a good VDR – April 2021 14 Apr, 2021
Vitamin D may also get into cells via TRPV1 (not just VDR) – April 2021 08 Apr, 2021
Spondyloarthritis 5X more likely if poor Vitamin D Receptor – Dec 2020 10 Mar, 2021
Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019 26 Feb, 2021
Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020 17 Feb, 2021
Vitamin D Receptor and Cancer 17 Feb, 2021
Leprosy, low Vitamin D and poor Vitamin D Receptor 17 Feb, 2021
Poor hip joint in infants associated with poor Vitamin D receptor – Jan 2021 31 Jan, 2021
Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021 15 Jan, 2021
Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020 31 Dec, 2020
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020 09 Dec, 2020
Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021 07 Dec, 2020
Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020 03 Dec, 2020
Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020 25 Nov, 2020
Vitamin D Receptor is associated in over 58 autoimmune studies 12 Nov, 2020
Uterine Fibroids (uterine leiomyoma, need hysterectomy) 1.9 more likely if a Vitamin D receptor problem – Sept 2015 28 Oct, 2020
Risk of Major Depressive Disorder increased 2.2 X by a poor Vitamin D receptor – Oct 2020 10 Oct, 2020
Glaucoma 3.1 X more likely if a poor Vitamin D Receptor – Sept 2020 03 Oct, 2020
Lumbar degenerative disc diseases can be prevented via Vitamin D Receptor – many studies 17 Sep, 2020
Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020 17 Sep, 2020
Metabolic Syndrome risk increases about 20 percent if poor Vitamin D Receptor – Aug 2020 10 Aug, 2020
UVB phototherapy (which increases Vitamin D and VDR) decreased risk of many heart and stroke problems – July 2020 29 Jul, 2020
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Respiratory problems in Children 1.4X more likely if poor Vitamin D receptor – April 2020 22 Jul, 2020
Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020 04 Jul, 2020
4X less of one chemo needed after vitamin D receptor activation - June 2020 02 Jun, 2020
Dengue virus 2X to 4X more likely if vitamin D receptor gene problems 08 May, 2020
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 02 May, 2020
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
3X reduction in Chemotherapy dose by Photodynamic Priming of Vitamin D Receptor (mice) – March 2020 30 Mar, 2020
Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018 10 Mar, 2020
Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020 26 Feb, 2020
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