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Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014

Impact of oral vitamin D (cholecalciferol) replacement therapy on blood pressure in type 2 diabetes patients; a randomized, double-blind, placebo controlled clinical trial.

J Nephropathol. 2014 Jan;3(1):29-33. doi: 10.12860/jnp.2014.07. Epub 2013 Dec 25.
Nasri H1, Behradmanesh S2, Ahmadi A3, Rafieian-Kopaei M4.
1Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
2Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: Vitamin D is an important mediator of calcium metabolism. It has also been implicated as a potential contributor to the pathophysiology of various extra-skeletal conditions, consisting hypertension, renal disease, and insulin resistance.

Objectives: The primary objective of this study was to determine whether oral vitamin D (cholecalciferol) supplementation can lead to improvement of blood pressure in type 2 diabetes patients.

Patients and Methods: This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks. Serum 25-Hydroxy vitamin D 25(OH)D level was measured with ELISA method.

Results: Five patients (8.3%) had vitamin D deficiency, 27 (45%) had insufficient levels of vitamin D and in 28 (45%) patients vitamin D level was within normal limits. The means of systolic blood pressure (BP) and diastolic BP in patients before intervention were 121 and 80.5 mmHg; after intervention they were 110 and 76.3 mmHg, respectively. After intervention, systolic and diastolic blood pressure levels were significantly less than control group (p< 0.01).

Conclusions: In this study we found that weekly vitamin D supplementation (cholecalciferol; 50,000 units for 12 weeks) had beneficial effect on the level of blood pressure in type 2 diabetic patients. Thus, oral vitamin D may help in improvement of hypertension in these patients.

PMID: 24644541

Summary by VitaminDWiki

Diastolic 80.576.3

It is amazing that the blood levels dropped so much, in a such a short time, with so many patients who had acceptable vitamin D levels, with so little added vitamin D.

PDF is attached at the bottom of this page

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3785 Blood pressure reduced in diabetics.pdf admin 10 Apr, 2014 219.34 Kb 1175