People with Osteoarthritis who took a lot of vitamin D had a nice side-effect – half the death rate – Sept 2022

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L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study

BMC Medicine volume 20, Article number: 308 (2022) https://doi.org/10.1186/s12916-022-02510-1
Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen & Ben He

Background
The relationship between vitamin D status and mortality in patients with osteoarthritis (OA) is unknown. This study investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among American adults with OA.

Methods
This study included 2556 adults with OA from the National Health and Nutrition Examination Survey (2001–2014). Death outcomes were ascertained by linkage to National Death Index (NDI) records through 31 December 2015. Cox proportional hazards model and two-piecewise Cox proportional hazards model were used to elucidate the nonlinear relationship between serum 25(OH)D concentrations and mortality in OA patients, and stratified analyses were performed to identify patients with higher mortality risk.

Results
During 16,606 person-years of follow-up, 438 all-cause deaths occurred, including 74 cardiovascular disease (CVD)-related and 78 cancer deaths. After multivariable adjustment, lower serum 25(OH)D levels were significantly and nonlinearly associated with higher risks of all-cause and CVD mortality among participants with OA. Furthermore, we discovered L-shaped associations between serum 25(OH)D levels and all-cause and CVD mortality, with mortality plateauing at 54.40 nmol/L for all-cause mortality and 27.70 nmol/L for CVD mortality. Compared to participants with 25(OH)D levels below the inflection points, those with higher levels had a 2% lower risk for all-cause mortality (hazard ratio [HR] 0.98, 95% confidence interval [CI] 0.96–0.99) and 17% lower risk for CVD mortality (HR 0.83, 95% CI 0.72–0.95).

Conclusions
Nonlinear associations of serum 25(OH)D levels with all-cause and CVD mortality were observed in American patients with OA. The thresholds of 27.70 and 54.40 nmol/L for CVD and all-cause mortality, respectively, may represent intervention targets for lowering the risk of premature death and cardiovascular disease, but this needs to be confirmed in large clinical trials.
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VitaminDWiki - Osteoarthritis category contains

59 items total - see also Overview Osteoporosis and vitamin D

Overview Osteoarthritis and Vitamin D
Knee Osteoarthritis treated by Vitamin D - meta-analysis Aug 2023
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020

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VitaminDWiki - Mortality starts category contains

People die sooner if they have low vitamin D

click on image for details

There are 312 articles in Mortality category

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Mortaility studes - Dr. Grant, etc.

Mortality

• Dr. Grant on vitamin D and mortality in VitaminDWiki
• Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
• 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
• Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
• Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
• Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
• 29 X more likely to die of COVID if less than 20 ng of Vitamin D - March 2022

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VitaminDWiki - 25 studies in both categories Cardiovascular and Mortality

This list is automatically updated