Table of contents
- L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study
- VitaminDWiki - Osteoarthritis category contains
- VitaminDWiki - Mortality starts category contains
- Mortaility studes - Dr. Grant, etc.
- VitaminDWiki -
22 studies in both categories Cardiovascular and Mortality
L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study
BMC Medicine volume 20, Article number: 308 (2022) https://doi.org/10.1186/s12916-022-02510-1
Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen & Ben He
Background
The relationship between vitamin D status and mortality in patients with osteoarthritis (OA) is unknown. This study investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among American adults with OA.Methods
This study included 2556 adults with OA from the National Health and Nutrition Examination Survey (2001–2014). Death outcomes were ascertained by linkage to National Death Index (NDI) records through 31 December 2015. Cox proportional hazards model and two-piecewise Cox proportional hazards model were used to elucidate the nonlinear relationship between serum 25(OH)D concentrations and mortality in OA patients, and stratified analyses were performed to identify patients with higher mortality risk.Results
During 16,606 person-years of follow-up, 438 all-cause deaths occurred, including 74 cardiovascular disease (CVD)-related and 78 cancer deaths. After multivariable adjustment, lower serum 25(OH)D levels were significantly and nonlinearly associated with higher risks of all-cause and CVD mortality among participants with OA. Furthermore, we discovered L-shaped associations between serum 25(OH)D levels and all-cause and CVD mortality, with mortality plateauing at 54.40 nmol/L for all-cause mortality and 27.70 nmol/L for CVD mortality. Compared to participants with 25(OH)D levels below the inflection points, those with higher levels had a 2% lower risk for all-cause mortality (hazard ratio [HR] 0.98, 95% confidence interval [CI] 0.96–0.99) and 17% lower risk for CVD mortality (HR 0.83, 95% CI 0.72–0.95).Conclusions
Nonlinear associations of serum 25(OH)D levels with all-cause and CVD mortality were observed in American patients with OA. The thresholds of 27.70 and 54.40 nmol/L for CVD and all-cause mortality, respectively, may represent intervention targets for lowering the risk of premature death and cardiovascular disease, but this needs to be confirmed in large clinical trials.
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VitaminDWiki - Osteoarthritis category contains
57 items total - see also Overview Osteoporosis and vitamin D Overview Osteoarthritis and Vitamin D
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See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020
VitaminDWiki - Mortality starts category contains
People die sooner if they have low vitamin D
There are
click on image for details292 articles in Mortality category 28 Mortality Meta-analyses This list is automatically updated
- Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- ICU patients 30 percent less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Less likely to die if have enough vitamin D - Meta-analysis June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis May 2012
- Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Vitamin D3 but not D2 reduces mortality – meta-analysis July 2011
- Vitamin D and mortality a meta-analysis of RCT - 2008
Mortaility studes - Dr. Grant, etc.
Mortality
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
- 29 X more likely to die of COVID if less than 20 ng of Vitamin D - March 2022
VitaminDWiki -
22 studies in both categories Cardiovascular and Mortality This list is automatically updated
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Metabolic Syndrome with low vitamin D increases CVD mortality by 1.7 X – July 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Predicted cardiac surgery death associated with low vitamin D levels – Dec 2012
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Did not find association between vitamin D and cardiovascular mortality – Sept 2010
- Table of outcomes for seniors vs vitamin D level
People with Osteoarthritis who took a lot of vitamin D had a nice side-effect – half the death rate – Sept 2022Printer Friendly Follow this page for updates420 visitors, last modified 22 Sep, 2022, This page is in the following categories (# of items in each category)Attached files
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