Vitamin D Supplementation on Premenstrual Syndrome-Related Mood Disorders in Adolescents with Severe Hypovitaminosis D.
J Pediatr Adolesc Gynecol. 2015 Dec 24. pii: S1083-3188(15)00444-1. doi: 10.1016/j.jpag.2015.12.006. [Epub ahead of print]
Tartagni M1, Cicinelli MV1, Tartagni MV2, Alrasheed H3, Matteo M1, Baldini D3, De Salvia M1, Loverro G1, Montagnani M4.
1Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, ITALY.
2Centro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, ITALY; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, ITALY.
3Centro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, ITALY.
4Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, ITALY. Electronic address: monica.montagnani at uniba.it.
158 young girls with < 10 nanograms of vitamin D
200,000 IU loading dose, followed by 25,000 every two weeks for 4 months
Reduced by about half: anxiety, irritability, Crying easily and sadness
See also VitaminDWiki
- PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018
- Menstrual Pain reduced by vitamin D – RCT 2012, 2014, 2016 RCT
Single dose of 300,000 IU of vitamin D
Women getting vitamin D needed NO pain relievers, vs 40% of the women without vitamin D
- Search VitaminDWiki for "premenstrual syndrome" OR PMS 54 items as of Jan 2016
- Overview Pain and Vitamin D
Premenstrual syndrome (PMS) may become severe enough to interfere with normal interpersonal relationships. This study was planned to assess whether administration of vitamin D (200.000 I.U. at first, followed by 25.000 I.U. every 2 weeks) for a 4 months period might be able to lessen the appearance and the intensity of mood disorders associated with PMS in young girls with severe hypovitaminosis D.
and Participants - One hundred-fifty eight young girls (15-21 years old) with PMS-related severe symptoms of the emotional and cognitive domains and low serum 25-hydroxycholecalciferol (25-OH-D) levels (≤ 10 ng/mL) were randomly assigned to two treatment groups and treated for 4 months with vitamin D (GROUP 1; n = 80) or placebo (GROUP 2; n = 78). Clinical and hormonal effects were compared between the two groups.
In patients from GROUP 1 - Vitamin D, levels of vitamin D reached the normal range (35-60 ng/ml) after the first month and remained stable throughout the whole study. At the end of treatment anxiety score decreased from 51 to 20 (P < 0.001 vs. baseline); irritability score declined from 130 to 70 (P < 0.001 vs. baseline). Crying easily and sadness decreased by a score of 41 and 51 to a score of 30 and 31, respectively (P < 0.001). For disturbed relationships, the score decreased from 150 to 70 (P < 0.001). Conversely, no appreciable changes were noted in symptom intensity from patients of GROUP 2 - Placebo. The frequency of adverse events (nausea and constipation) was not different between participants of GROUP 1 and GROUP 2.
- Based on present findings, vitamin D therapy can be proposed as a safe, effective and convenient method for improving the quality of life in young women with severe hypovitaminosis D and concomitant mood disorders associated to PMS.
Copyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
- Vitamin D Deficiency Effects On Menstrual Pain:
- Vitamin D Improves Mood Disorders in D-Deficient Girls With PMS AAPGGrand Rounds April 2016
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