European Resp. Journal DOI: 10.1183/13993003.congress-2015.PA2559 Published 1 September 2015
Anupam Malik, Balakrishnan Menon, Yusuf Dar, Tinu Garg, Harish Bhatia, Charanjeet Kaur
Introduction: Increasing evidence is linking Vitamin D to immune-related conditions. Lymphocytes have Vitamin D Receptors and Vitamin D has direct affects on dendritic cells, helper and regulatory T cells and activated B cells.
Aims and Objectives: To evaluate the levels of Vitamin D in Allergic Rhinitis and its correlation with the severity of disease and the effect Vitamin D supplementation (Cholecalciferol - 1000 IU) on the course of the disease.
Material & Methods: Fifty subjects of Allergic Rhinitis were randomised into two groups. The test group received oral vitamin D (cholecalciferol; 1000 IU) for thirty days while the Control group received placebo. Vitamin D levels and Total Nasal Symptom Score (TNSS) were assessed at the start and end of the study period.
Results: Patients of allergic rhinitis showed deficiency in vitamin D levels. The mean vitamin D level in Test group was 17.32+8.26 ng/ml and in Control group was 18.19±4.66 ng/ml . The TNSS score was 9.92±1.37 in Test group and 10.17±2.90 in Control group.
The Post treatment mean vitamin D level was 29.71±2.28 ng/ml in test group and 18.67±4.75 ng/ml in Control group and the TNSS scores was 2.81±3.04 and 5.42±7.78 respectively. This difference between groups was significant. There was significant correlation between the severity of disease as represented by the different TNSS groups and Vitamin D levels.
Conclusion: Vitamin D levels were found to be low in subjects with allergic rhinitis. The levels of Vitamin D correlated with the severity of disease. There was highly significant reduction in the total nasal symptom score after supplementation. Thus Vitamin D supplementation alters the course of Allergic Rhinitis towards clinical improvement.
Studies in both Intervention AND Breathing categories
- Childhood colds reduced by weekly 14,000 IU of Vitamin D – after 3 months – RCT Jan 2019
- All asthma problems reduced after 1 year of Vitamin D – Nov 2017
- Asthma treated by daily 50,000 IU of Vitamin D – April 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017
- Influenza -A infections half as often in children getting 1200 IU of vitamin D – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D – June 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls – Nov 2016
- RTI – Feel much better if increase vitamin D level above 40 ng (4000 IU) – RCT Sept 2015
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015
- Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015
- Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015
- Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
- Respiratory infections cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- Loading dose of 500,000 IU vitamin D increased hemoglobin in critical illness – RCT April 2015
- Respiratory diseases helped by vitamin D if initially have low level – RCT review Jan 2015
- COPD reduced by vitamin D taken once every 60 days – RCT Dec 2014
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- Allergy to House dust mite greatly reduced by adding just 600 IU of vitamin D – RCT Nov 2014
- Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013
- COPD Overview
- Respiratory infections reduced by 63 percent with 4000 IU vitamin D daily - RCT Dec 2012
- Just 300 IU daily of vitamin D reduced respiratory infections by 50% – RCT Aug 2012
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 100000 IU vitamin D monthly helps COPD patients – 3 RCT