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Arterial stiffness reduced by a single dose of 100,000 IU of vitamin D – RCT Dec 2014

The effect of Vitamin D supplementation on arterial stiffness in an elderly community based population

J. of the American Society of Hypertension , online Dec 31, 2014 doi:10.1016/j.jash.2014.12.019
C. McGreevya, cmcgreevy at mater.i.e. , M. Barrya, C. Davenportb, B. Byrnec, C. Donaghyc, G. Collierc, W. Tormeyd, D. Smithb, K. Bennette, D. Williamsa,

VitaminDWiki Comment
  • Arterial stiffness measure (PWM) reduced from 12.2 to 12.0 by a single injection of 100,000 IU Vitamin D
  • Even though only 6% of the people got above 30 ng level of vitamin D
  • VitaminDWiki expects that far less hypertension if more vitamin D was used and a higher % of people had gotten to > 30 ng
  • Injection does not appear to be necessary

Aims
Vitamin D deficiency may lead to impaired vascular function and abnormalities in central arterial stiffness. We compared the effects of two different doses of vitamin D3 on arterial stiffness in an elderly population with deficient serum 25OHD levels.

Methods
119 known vitamin D deficient(<50nmol/L) subjects were randomised to receive either 50,000IU or 100,000IU single IM vitamin D3.

Results
In the group that received 100,000IU vitamin D, median PWV

  • decreased from 12.2(5.1-40.3) m/sec
  • to 11.59(4.3-14.9) m/sec after 8 weeks (p=0.22).

A mean decrease of 3.803+/-1.7(p=0.032) in Augmentation Index (Aix)( a measure of systemic stiffness) was noted.
Only 3/51(5.8%) who received 100,000IU vitamin D reached levels of sufficiency (>75nmol/L).

Conclusions
A significant decrease in Augmentation index was seen in the group that received 100,000IU vitamin D. Serum levels of 25-hydroxyvitamin D were still deficient at 8 weeks in the majority of patients which may be attributable to impaired bioavailability.

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