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Metabolic Syndrome risk reduced 44 percent when vitamin D levels increased by 30 nanograms – Aug 2015

The Effect of Changing Serum 25-Hydroxyvitamin D Concentrations on Metabolic Syndrome: A Longitudinal Analysis of Participants of a Preventive Health Program.

Nutrients. 2015 Aug 28;7(9):7271-7284.
Pham TM1, Ekwaru JP2, Setayeshgar S3, Veugelers PJ4.

Several studies have shown that a poor vitamin D status may increase the risk of developing metabolic syndrome, which leaves the question whether improving one's vitamin D status may reduce the risk for the syndrome. Here we investigate the effect of temporal changes in serum 25-hydroxyvitamin D (25(OH)D) concentrations on metabolic syndrome among Canadians enrolled in a preventive health program that promotes vitamin D supplementation. We accessed and analyzed data of 6682 volunteer participants with repeated observations on serum 25(OH)D concentrations and metabolic syndrome. We applied logistic regression to quantify the independent contribution of baseline serum 25(OH)D and temporal increases in serum 25(OH)D to the development of metabolic syndrome. In the first year in the program, participants, on average, increased their serum 25(OH)D concentrations by 37 nmol/L. We observed a statistical significant inverse relationship of increases in serum 25(OH)D with risk for metabolic syndrome. Relative to those without improvements, those who improved their serum 25(OH)D concentrations with less 25 nmol/L, 25 to 50 nmol/L, 50 to 75 nmol/L, and more 75 nmol/L had respectively 0.76, 0.64, 0.59, 0.56 times the risk for metabolic syndrome at follow up. These estimates were independent of the effect of baseline serum 25(OH)D concentrations on metabolic syndrome. Improvement of vitamin D status may help reduce the public health burden of metabolic syndrome, and potential subsequent health conditions including type 2 diabetes and cardiovascular disease.

PMID: 26343719
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Review of this study at Vitamin D Council

"What struck me first were the baseline levels of 25(OH)D and prevalence of metabolic syndrome. As baseline levels rose from < 20 ng/ml to > 50 ng/ml, the prevalence of metabolic syndrome was almost four times less."

Attached files

ID Name Comment Uploaded Size Downloads
5898 Response vs years.jpg admin 08 Sep, 2015 11:55 35.60 Kb 852
5897 Metabolic Syndrom risk.jpg admin 08 Sep, 2015 11:54 93.07 Kb 767
5896 Metabolic Syndrome.pdf PDF 2015 admin 08 Sep, 2015 11:54 197.94 Kb 396
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