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Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017

Role of Vitamin D in the Outcome of Ischemic Stroke- A Randomized Controlled Trial

Journal of Clinical and Diagnostic Research 2017 February. DOI: 10.7860/JCDR/2017/24299.9346

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Shuba Narasimhan, Prakash Balasubramanian
1. Associate Professor, Department of Physiology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India. 2. Professor, Department of Neurology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
Dr. Shuba Narasimhan, Associate Professor, Department of Physiology, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore-641004, Tamil Nadu, India. E-mail: shubaphysio at gmail.com

Introduction: Vitamin D deficiency has reached epidemic proportions in India with prevalence rates of 70-100% in the general population. Low vitamin D levels are associated with worse outcomes in ischemic strokes. The outcome of stroke after vitamin D replenishment has not been much studied.

Aim: To compare the stroke outcome between patients receiving vitamin D supplementation and patients without vitamin D supplementation by Scandinavian Stroke Scale (SSS) and thus, to assess the long term outcome of ischemic stroke patients with low vitamin D level by supplementation of vitamin D.

Materials and Methods: This is a non blinded randomized controlled trial conducted in ischemic stroke patients. The patients were divided into two groups (A and B ) where Group A received a single dose of 6 lac IU of Cholecalciferol Intramascular (IM) injection and Group B were not given vitamin D. Finally 30 patients in each group were analyzed. SSS was applied to evaluate the stroke severity at the onset and at the follow up after three months in both groups. The difference in SSS was analyzed using SPSS software. Independent t-test was applied and p-value < 0.05 was taken as significant.

Results: Mean±SD of vitamin D levels in Group A and Group B were 17.98±3.81ng/ml and 18.44±4.69 ng/ml respectively. Mean±SD of SSS at time of admission and after three months for Group A was 32.50±11.61 and 38.89±8.34; and for Group B 35.82±8.56 and 38.32±7.10. The difference in SSS from time of admission and after three months, in Group A (6.39±4.56) and Group B (2.50±2.20) were analyzed statistically and found to be highly significant (p<0.001).

Conclusion: The results showed that there is a significant improvement in the stroke outcome after three months in those patients who were supplemented with vitamin D. Thus screening for vitamin D deficiency in stroke patients is essential and vitamin D replenishment will improve the stroke outcome.

Attached files

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7764 Stroke.jpg admin 02 Mar, 2017 13.82 Kb 1224
7763 schemic Stroke.pdf admin 02 Mar, 2017 1.28 Mb 1303