Effect of Vitamin D Supplement on Influenza A Illness during the 2009 H1N1 Pandemic: A Randomized Controlled Trial
Food Funct., 2014, DOI: 10.1039/C4FO00371C, First published online 14 Jul 2014
Mitsuyoshi Urashima, Hidetoshi Mezawa, Miki Noya and Carlos A. Camargo
In a prior randomized trial, we found that incidence of influenza A was less in vitamin D3 group than among those on placebo, but total incidence of either influenza A or B did not differ between groups.
In this trial, incidence of influenza A or B was less in vitamin D3 group than in placebo group only during the first half of the study.
To elucidate whether vitamin D3 had preventive actions against influenza A, we conducted another trial during the 2009 pandemic of the H1N1 subtype of influenza A.
Students (n=247) of a Japanese high school were randomly assigned to receive vitamin D3 supplements (n=148; 2000 IU/day) or placebo (n=99) in double-blind setting for 2 months.
The primary outcome was incidence of influenza A diagnosed with rapid influenza diagnostic test by medical doctors. Influenza A was equally likely in the vitamin D3 group (20/148: 13.5%) compared with placebo group (12/99: 12.1%).
By post hoc analysis, influenza A occurred significantly less in vitamin D3 group (2/148: 1.4%)
compared with placebo group (8/99: 8.1%) (risk ratio, 0.17; 95% confidence interval, 0.04 to 0.77; P=0.009) in the first month.
However, during the second month, vitamin D3 group experienced more events and effectively caught up with the placebo group. Vitamin D3 supplementation did not lower overall incidence of influenza A during the 2009 H1N1 pandemic. A post hoc analysis suggests that the initial benefit during the first month of treatment was lost during the second month.
- More daily vitamin D
- Loading dose initially
- Overview Influenza and vitamin D
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
Note: 1200 IU for a 3 year old child is a lot more powerful than 2,000 IU for a teen - huge difference in body weight