Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.
Osteoporos Int. 2015 May 9. [Epub ahead of print]
Cangussu LM 1 lucianacangussu at gmail.com, Nahas-Neto J, Orsatti CL, Bueloni-Dias FN, Nahas EA.
postmenopausal women with a history of falls (associated with low vitamin D)
1,000 IU daily for 9 months
|Vitamin D at start||15 ng||17 ng|
|Vitamin D after 9 months||28 ng||14 ng|
|Muscle strength lower limbs||+25 %|
|Loss of lean muscle mass||-7 %|
See also VitaminDWiki
Sarcopenia (muscle loss) and Vitamin D
The present study investigates the effects of vitamin D on muscle function in postmenopausal women. It has been shown that vitamin D supplementation in postmenopausal women with hypovitaminosis D provides significant protective factor against sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass.
We aimed to evaluate the effect of supplementation of vitamin D (VITD) alone on muscle function in younger postmenopausal women.
In this double-blind, placebo-controlled clinical trial, 160 Brazilian postmenopausal women were randomized into two groups: VITD group consisting of patients receiving vitamin D3 1000 IU/day orally (n = 80) or placebo group (n = 80). Women with amenorrhea for more than 12 months and age 50-65 years, with a history of falls (previous 12 months), were included. The intervention time was 9 months, with assessments at two points, start and end. Lean mass was estimated by total-body dual-energy X-ray absorptiometry (DXA) and muscle strength by handgrip strength and chair rising test. The plasma concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by high-performance liquid chromatography (HPLC). Statistical analysis was by intention to treat (ITT), using ANOVA, Student's t test, and Tukey's test.
After 9 months, average values of 25(OH)D increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/ml (+45.4 %) in the VITD group and decreased from 16.9 ± 6.7 to 13.8 ± 6.0 ng/ml (-18.5 %) in the placebo group (p < 0.001). In the VITD group, there was significant increase in muscle strength (+25.3 %) of the lower limbs by chair rising test (p = 0.036). In women in the placebo group, there was considerable loss (-6.8 %) in the lean mass (p = 0.030).
The supplementation of vitamin D alone in postmenopausal women provided significant protective factor against the occurrence of sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass.
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- Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015
- Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014
- Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014
- Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016
- RCT: Vitamin D supplementation protects against muscle wasting Vitamin D Council review of this study
- News Release when study presented at conference in Oct 2015
"Women not receiving Vitamin D supplements were also nearly two times as likely to fall"