Loading...
 
Translate Register Log In Login with facebookLogin and Register

Bacterial vaginosis reduced 10 times by 2,000 IU of vitamin D – RCT June 2015

Treatment of vitamin D deficiency is an effective method in the elimination of asymptomatic bacterial vaginosis: A placebo- controlled randomized clinical trial

Indian J Med Res 141, June 2015, pp 799-806 DOI:10.4103/0971-5916.160707
Mahshid Taheri1, Azam Baheiraei2, Abbas Rahimi Foroushani3, Bahram Nikmanesh4 & Maryam Modarres1
1Department of Midwifery, School of Nursing & Midwifery,
2Reproductive Health Department, Tehran University of Medical Sciences,
3Departments of Epidemiology & Biostatistics & Medical Parasitology & Mycology,
School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Background & objectives: Bacterial vaginosis (BV) is the most prevalent vaginal infection in women of reproductive age group which has been found to be associated with vitamin D deficiency. The purpose of this study was to investigate the effectiveness of the administration of 2000 IU/day edible vitamin D for 15 wk to eliminate asymptomatic BV among reproductive age women with vitamin D deficiency.

Methods: A total of 208 women with asymptomatic BV, who were found to be eligible after interviews and laboratory tests, were randomly assigned to a control group (n=106) or an intervention group (n=105). They used vitamin D drops daily for 105 days. Vaginal and blood samples were taken before and after the second intervention using identical methods (Nugent score for BV diagnosis, serum 25-hydroxyvitamin D for vitamin D determination).

Results: The cure rate of asymptomatic BV was

  • 63.5 per cent in the intervention and
  • 19.2 per cent in the control group (P <0.001).

The results showed that being unmarried (P=0.02), being passive smoker (P<0.001), and being in the luteal phase of a menstrual cycle during sampling (P=0.01) were significantly associated with post-intervention BV positive results.
After these elements were controlled, the odds of BV positive results in the control group was 10.8 times more than in the intervention group (P<0.001).

Interpretation & conclusions: Among women in reproductive age group with vitamin D deficiency, the administration of 2000 IU/day edible vitamin D was effective in eliminating asymptomatic BV. This treatment could be useful in preventing the symptoms and side effects of BV.

 Download the PDF from VitaminDWiki


See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
5696 bacterial vaginosis.pdf PDF 2015 admin 20 Jul, 2015 00:06 451.72 Kb 393
See any problem with this page? Report it (FINALLY WORKS)