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Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016

Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial.

Medicine (Baltimore). 2016 Dec;95(52):e5353. doi: 10.1097/MD.0000000000005353.
Nowak A1, Boesch L, Andres E, Battegay E, Hornemann T, Schmid C, Bischoff-Ferrari HA, Suter PM, Krayenbuehl PA.
aDepartment of Internal Medicine
bInstitute for Clinical Chemistry, University Hospital Zurich and University of Zurich
cDivision of Endocrinology, Diabetology and Clinical Nutrition
dDepartment of Geriatrics, University Hospital Zurich, Zurich
eDepartment of Internal Medicine, Spital Linth, Uznach, Switzerland.

VitaminDWiki Summary

Men and women with self-reported fatigue who were vitamin D deficient
Gave them a single 100,000 IU dose of vitamin D or placebo
Fatigue assessment scale at one month: -3.3 for vitamin D vs -0.8 for placebo
VitaminDWiki Comment

  • It is unlikely that 100,000 IU would have gotten many participants to a good level of vitamin D
  • Expect far more reduction in fatigue (as well as pain) if use a loading dose of 400,000 IU
  • To keep the pain away, a the loading dose needs to be followed by maintenance doses
    Typically 50,000 IU every two weeks

See details in VitaminDWiki

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BACKGROUND:
Vitamin D deficiency is frequent and has been associated with fatigue in uncontrolled trials.

METHODS:
This is the first double-blind placebo-controlled clinical trial to investigate the efficacy of per os vitamin D3 (cholecalciferol) in treating fatigue among otherwise healthy persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and vitamin D deficiency (serum 25(OH)D < 20 µg/L). Participants were randomized to a single oral dose of 100,000 units of vitamin D or placebo. The primary endpoint was intra-individual change in the fatigue assessment scale (FAS) at 4 weeks after treatment.

RESULT:
The mean age of the participants was 29 ± 6 years, 53% were women. Mean FAS decreased significantly more in the vitamin D group (-3.3 ± 5.3; 95% confidence interval [CI] for change -14.1 to 4.1) compared with placebo (-0.8 ± 5.3; 95% CI for change -9.0 to 8.7); (P = 0.01). Amelioration of fatigue was reported more frequently in vitamin D than in placebo group (42 [72%] vs. 31 [50%]; P = 0.01; odds ratio [OR] 2.63, 95% CI for OR 1.23-5.62). Among all participants, improvement in fatigue score correlated with the rise in 25(OH)D level (R = -0.22, P = 0.02).

CONCLUSION:
Vitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.

This study was registered at the www.ClinicalTrials.gov Protocol ID NCT02022475.
PMID: 28033244 DOI: 10.1097/MD.0000000000005353

 Download the PDF from VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
7746 Fatigue 28 day.jpg admin 27 Feb, 2017 22:57 23.35 Kb 1867
7745 self-perceived fatigue.pdf PDF 2016 admin 27 Feb, 2017 22:54 296.37 Kb 221
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