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Poor motor development in infant was 40 percent more likely if low maternal vitamin D – July 2017

Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC).

Br J Nutr. 2017 Jul 12:1-11. doi: 10.1017/S0007114517001398. [Epub ahead of print]

VitaminDWiki
  • Vitamin D is shown yet again to be very important during pregnancy
  • Several randomized controlled trials have found deficiency during pregnancy was eliminated by $10 of vitamin D

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial


 Download the PDF from VitaminDWiki

Even higher risk of motor problems if material Vit D < 10 ng

Image

Darling AL1, Rayman MP1, Steer CD2, Golding J2, Lanham-New SA1, Bath SC1.

  • 1 Department of Nutritional Sciences,School of Biosciences and Medicine, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7XH,UK.
  • 2 School of Social and Community Medicine,Centre for Child and Adolescent Health,University of Bristol,Bristol BS8 2BN,UK.

Seafood intake in pregnancy has been positively associated with childhood cognitive outcomes which could potentially relate to the high vitamin D content of oily fish. However, whether higher maternal vitamin D status (serum 25-hydroxyvitamin D OH)D in pregnancy is associated with a reduced risk of offspring suboptimal neurodevelopmental outcomes is unclear. A total of 7065 mother-child pairs were studied from the Avon Longitudinal Study of Parents and Children cohort who had data for both serum total 25(OH)D concentration in pregnancy and at least one measure of offspring neurodevelopment (pre-school development at 6-42 months; 'Strengths and Difficulties Questionnaire' scores at 7 years; intelligence quotient (IQ) at 8 years; reading ability at 9 years).
After adjustment for confounders, children of vitamin D-deficient mothers (<50·0 nmol/l) were more likely to have scores in the lowest quartile for

  • gross-motor development at 30 months (OR 1·20; 95 % CI 1·03, 1·40),
  • fine-motor development at 30 months (OR 1·23; 95 % CI 1·05, 1·44) and
  • social development at 42 months (OR 1·20; 95 % CI 1·01, 1·41)

than vitamin D-sufficient mothers (≥50·0 nmol/l). No associations were found with neurodevelopmental outcomes, including IQ, measured at older ages. However, our results suggest that deficient maternal vitamin D status in pregnancy may have adverse effects on some measures of motor and social development in children under 4 years. Prevention of vitamin D deficiency may be important for preventing suboptimal development in the first 4 years of life.

PMID: 28697816 DOI: 10.1017/S0007114517001398

Created by admin. Last Modification: Thursday July 13, 2017 15:54:08 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
8178 Dev 10 vs 20 ng.jpg admin 13 Jul, 2017 15:09 84.61 Kb 124
8177 Maternal deficiency and 3 year development.pdf PDF 2017 admin 13 Jul, 2017 15:08 515.40 Kb 267
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