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Dementia is associated with low vitamin D - several studies


Overview Alzheimer's-Cognition and Vitamin D

has the following summary


Dementia 1.8X more likely if low Vitamin D - April 2022

Vitamin D and brain health: an observational and Mendelian randomization study
Am J Clin Nutr . 2022 Apr 22;nqac107. doi: 10.1093/ajcn/nqac107.
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Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis - 2017

BMC Geriatrics volume 17, Article number: 16 (2017)
Isolde Sommer, Ursula Griebler, Christina Kien, Stefanie Auer, Irma Klerings, Renate Hammer, Peter Holzer & Gerald Gartlehner
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Background
Sunlight exposure and high vitamin D status have been hypothesised to reduce the risk of developing dementia. The objective of our research was to determine whether lack of sunlight and hypovitaminosis D over time are associated with dementia.

Methods
We systematically searched MEDLINE (via PubMed), Cochrane Library, EMBASE, SCOPUS, Web of Science, ICONDA, and reference lists of pertinent review articles from 1990 to October 2015. We conducted random effects meta-analyses of published and unpublished data to evaluate the influence of sunlight exposure or vitamin D as a surrogate marker on dementia risk.

Results
We could not identify a single study investigating the association between sunlight exposure and dementia risk. Six cohort studies provided data on the effect of serum vitamin D concentration on dementia risk. A meta-analysis of five studies showed a higher risk for persons with serious vitamin D deficiency (<25 nmol/L or 7–28 nmol/L) compared to persons with sufficient vitamin D supply (≥50 nmol/L or 54–159 nmol/L) (point estimate 1.54; 95% CI 1.19–1.99, I2 = 20%). The strength of evidence that serious vitamin D deficiency increases the risk of developing dementia, however, is very low due to the observational nature of included studies and their lack of adjustment for residual or important confounders (e.g. ApoE ε4 genotype), as well as the indirect relationship between Vitamin D concentrations as a surrogate for sunlight exposure and dementia risk.

Conclusions
The results of this systematic review show that low vitamin D levels might contribute to the development of dementia. Further research examining the direct and indirect relationship between sunlight exposure and dementia risk is needed. Such research should involve large-scale cohort studies with homogeneous and repeated assessment of vitamin D concentrations or sunlight exposure and dementia outcomes.


Quality assessment of systematic reviews of vitamin D, cognition and dementia - 2018

BJPsych Open. 2018 Jul;4(4):238-249. doi: 10.1192/bjo.2018.32.
Aghajafari F1, Pond D2, Catzikiris N3, Cameron I4.

  • 1 Assistant Professor, Dept of Family Medicine, Cumming School of Medicine, U. of Calgary Sunridge Family Medicine Teaching Centre, Canada.
  • 2 Professor and Head of Department of Family Medicine, University of Newcastle, Australia.
  • 3 Research Assistant, School of Medicine and Public Health, Faculty of Medicine, The University of Newcastle, Australia.
  • 4 Professor, Northern Clinical School, Rehabilitation Studies Unit, Sydney Medical School, The University of Sydney, Australia.

BACKGROUND: There is conflicting evidence regarding the association of vitamin D with cognition performance and dementia.

Aims We aimed to summarise the evidence on the association of vitamin D with cognitive performance, dementia and Alzheimer disease through a qualitative assessment of available systematic reviews and meta-analyses.

METHOD: We conducted an overview of the systematic reviews of all study types with or without meta-analyses on vitamin D and either Alzheimer disease, dementia or cognitive performance up to June 2017.

RESULTS:
Eleven systematic reviews were identified, nine of which were meta-analyses with substantial heterogeneity, differing statistical methods, variable methodological quality and quality of data abstraction. A Measurement Tool to Assess Systematic Reviews checklist scores ranged from 4 to 10 out of 11, with seven reviews of 'moderate' and four of 'high' methodological quality.
Out of six meta-analyses on the association between low serum concentration of 25-hydroxyvitamin D and risk of dementia, five showed a positive association. Results of meta-analyses on the association between low serum concentration of 25-hydroxyvitamin D and memory function tests showed conflicting results.

CONCLUSIONS:
This systematic evaluation of available systematic reviews provided a clearer understanding of the potential link between low serum vitamin D concentrations and dementia. This evaluation also showed that the quality of the available evidence is not optimal because of both the low methodological quality of the reviews and low quality of the original studies. Interpretation of these systematic reviews should therefore be made with care.


VITAMIN D AND DEMENTIA - 2016

J Prev Alz Dis 2016;3(1):43-52 http://dx.doi.org/10.14283/jpad.2015.68 full text and graphics at the website
T.J. Littlejohns1,2, K. Kos2, W.E. Henley2, E. Kuźma2, D.J. Llewellyn 2 llewellyn at exeter.ac.uk
1. Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK;
2. University of Exeter Medical School, University of Exeter, Exeter, UK

Emerging evidence suggests that low vitamin D concentrations are potentially involved in the pathogenesis of dementia. This is of particular interest when considering the high prevalence of vitamin D deficiency in elderly adults and the urgent need to identify modifiable risk factors for dementia. Studies have found that vitamin D is implicated in procognitive and neuroprotective functions, including the reduction of Alzheimer’s disease hallmarks such as amyloid beta and phosphorylated tau. Cross-sectional studies have consistently found that vitamin D concentrations are significantly lower in individuals with Alzheimer’s disease and cognitive impairment compared to healthy controls. Longitudinal studies support an association between low vitamin D concentrations and an increased risk of dementia and cognitive decline. Neuroimaging studies are beginning to uncover the potential neurodegenerative and cerebrovascular mechanisms that underlie these associations such as white matter hyperintensities and enlarged ventricular volume, although there is currently a lack of longitudinal studies. In contrast to observational studies, findings from interventional studies have produced mixed results on the benefits of vitamin D supplementation on dementia and cognitive outcomes. Interpretation of the findings from these studies is hampered by several major methodological limitations, such as small sample sizes, inadequate doses and inclusion of participants unlikely to benefit from vitamin D supplementation. There is a need for large double-blind randomised-control trials investigating whether vitamin D supplementation can halt or delay the risk of dementia-related outcomes in individuals with low vitamin D concentrations.


Vitamin D pages containing "Dementia" in title (41 as of May 2022)

Items found: 41
Title Modified
Dementia is associated with low vitamin D - several studies 15 Jun, 2022
Vitamin Supplementation and Dementia - Review May 2022 11 May, 2022
Lewy Body Dementia (Robin Williams) and low Vitamin D 11 May, 2022
Dementia 10X lower in a group who are outdoors a lot and eat unprocessed foods - March 2022 07 Apr, 2022
Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022 07 Apr, 2022
Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022 14 Feb, 2022
Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 22 Nov, 2021
Dementia reduced 26 percent after pollution was reduced a decade earlier (probably higher Vitamin D) – Aug 2021 19 Aug, 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020 08 Jan, 2021
The Evidence is strong: Air pollution seems to cause dementia (perhaps low Vitamin D) – May 2019 09 May, 2019
Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019 04 Feb, 2019
Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018 17 Jan, 2019
Why dementia gets more severe in the winter – Jan 2019 14 Jan, 2019
Vitamin D and neurological diseases such as stroke, Vascular Dementia, PD, MS - July 2018 07 Dec, 2018
Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 21 Aug, 2018
Dementia – clinical trial using 4,000 IU of Vitamin D– 2023 02 Aug, 2018
Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 12 May, 2018
Dementia less likely with increased levels of Magnesium etc. 18 Apr, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Off Topic: Dementia risk reduced 90 percent if woman had been highly fit 40 years before 18 Mar, 2018
Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 16 Feb, 2018
Should you have a dementia advanced directive - Jan 2018 19 Jan, 2018
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 23 Nov, 2017
Heart Attack increased risk of vascular dementia by 1.35 X (both associated with low vitamin D) Oct 2017 15 Nov, 2017
Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017 15 Jan, 2017
Dementia 19X more likely if low vitamin D – Jan 2012 27 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (nope) - Oct 2015 04 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (not a surprise) - Oct 2015 04 Oct, 2016
Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015 11 Dec, 2015
Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 01 Nov, 2015
Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014 03 Oct, 2015
Dementia 13X more likely in elderly with low vitamin D – May 2014 04 Sep, 2015
Dementia risk increases with latitude (less vitamin D) - Feb 2015 20 Feb, 2015
Chance of Dementia increased 3 percent for every 1 ng less of vitamin D – Feb 2015 04 Feb, 2015
The Single Vitamin That's a Double Whammy Against Both Depression and Dementia (Mercola) – Aug 2014 21 Aug, 2014
More depression associated with more dementia in seniors (vitamin D not mentioned) – July 2014 31 Jul, 2014
Age-adjusted dementia may be declining – NEJM Dec 2013 01 Jan, 2014
Dementia risk increases 60 percent if have low vitamin D – Nov 2012 16 Dec, 2013
Dementia associated with low vitamin D in two thirds of studies – systematic review May 2013 01 Aug, 2013
Vitamin D might might reduce dementia – Mar 2011 23 Jun, 2012

How to Communicate With People Suffering From Dementia - April 2022 - nothing about Vitamin D

Wall Street Journal   PDF

  • "Anne Basting says the key is to not ask questions that force those with Alzheimer’s to remember facts. Instead, focus on creative and emotional communication."

Dementia is also associated with Magnesium

  • Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort - Oct 2020 1.2X PDF
  • Serum magnesium is associated with the risk of dementia - 2017 BOTH high and low Mg PDF via Sci-Hub
  • Association between magnesium intake and cognition in US older adults: National Health and Nutrition Examination Survey (NHANES) 2011 to 2014 - Feb 2022 PDF

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Created by admin. Last Modification: Wednesday June 15, 2022 10:31:11 GMT-0000 by admin. (Version 19)

Attached files

ID Name Comment Uploaded Size Downloads
17881 magnesium intake and cognition in US.pdf admin 15 Jun, 2022 10:33 602.55 Kb 6
17880 Incident Dementia.pdf admin 15 Jun, 2022 10:31 352.39 Kb 0
17879 Dementia Mg Sci-Hub.pdf admin 15 Jun, 2022 10:25 387.68 Kb 0
17483 How to Communicate With People Suffering From Dementia - WSJ.pdf PDF 2022 admin 23 Apr, 2022 17:45 209.15 Kb 18
17475 Brain health.pdf PDF 2022 admin 22 Apr, 2022 19:02 924.95 Kb 23
14234 Dementia Meta 2017.pdf admin 01 Sep, 2020 11:50 526.15 Kb 206
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