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Pregnancies helped by Vitamin D in many ways – 27th meta-analysis Jan 2019

Vitamin D status during pregnancy and offspring outcomes: a systematic review and meta-analysis of observational studies

European Journal of Clinical Nutrition (2019). https://doi.org/10.1038/s41430-018-0373-x
Monica Tous, Marcela Villalobos, Lucia Iglesias, Sílvia Fernández-Barrés & Victoria Arija

VitaminDWiki

Pregnancy category starts with

725 items in Pregnancy category

 - see also


Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


The articles in Pregnancy AND Meta-analysis are here:


A very few completely disagree

 Download the PDF from Sci-Hub via VitaminDWiki

Background/objectives
Vitamin D deficiency during pregnancy may influence adverse outcomes in offspring. The aim of this systematic review and meta-analysis of observational studies was to assess the association between low prenatal concentrations of 25(OH)D (by using three different cut-off levels), preterm birth (PTB) and anthropometric and neurodevelopmental outcomes in offspring.

Subjects/methods
Studies reporting data on the association between maternal vitamin D concentrations and offspring outcomes identified through a systematic review of scientific literature published in PubMed/MEDLINE, Scopus and the Cochrane Library databases up to April 2017.

Results
We included 54 eligible studies. Vitamin D-deficient mothers (<30 nmol/L) had offspring with *lower birthweight (MD −87.82 g; 95% CI −119.73, −55.91 g),

  • (smaller) head circumference (MD −0.19 cm; 95% CI −0.32, −0.06 cm) and a
  • higher risk of small for gestational age (SGA) infants and
  • PTB (OR 1.59; 95% CI 1.24, 2.03)

compared to mothers with concentrations ≥30 nmol/L.

Vitamin D insufficiency (<50 nmol/L) was associated with a

  • higher risk of SGA (OR 1.43; 95% CI 1.08, 1.91 and

higher risk of PTB OR 1.28; 95% CI 1.08, 1.52
Concentrations of 25(OH)D ≥75 nmol/L were not found to be associated with birthweight, SGA or PTB.
Offspring of vitamin D-insufficient mothers had lower scores in

  • mental (MD −1.12 points; 95% CI −1.82, −0.42 cm) and
  • language developmental tests (MD −0.35 points; 95% CI −1.00, 0.31 cm).

Conclusion
Maternal vitamin D deficiency is associated with offspring adverse anthropometric outcomes and PTB; insufficiency with a higher risk of SGA, PTB and adverse neurodevelopmental outcomes.

Created by admin. Last Modification: Friday January 25, 2019 18:42:46 GMT-0000 by admin. (Version 6)

Attached files

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11270 Pregnacy meta Jan 2019.pdf PDF 2019 admin 25 Jan, 2019 16:58 3.30 Mb 61
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